1. Immunology/Inflammation
  2. Interleukin Related
  3. Tucotuzumab

Tucotuzumab  (Synonyms: Anti-EPCAM Recombinant Antibody; huKS-IL2)

目录号: HY-P99328 纯度: ≥95.0%
COA

Tucotuzumab (Anti-EPCAM Recombinant Antibody) 一种由靶向人上皮细胞粘附分子 (EpCAM) 的抗原特异性 IgG1 单克隆抗体。Tucotuzumab 可连接两个 IL-2 分子,是一种免疫抑制剂和抗肿瘤活性分子。

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Tucotuzumab Chemical Structure

Tucotuzumab Chemical Structure

CAS No. : 339986-90-2

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规格 价格 是否有货 数量
1 mg ¥2600
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5 mg ¥6800
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tucotuzumab (Anti-EPCAM Recombinant Antibody) is an antigen-specific IgG1 monoclonal antibody that targets human epithelial cell adhesion molecule (EpCAM). Tucotuzumab links two IL-2 molecules and is an immunosuppressant and anti-tumor active molecule[1].

体外研究
(In Vitro)

Tucotuzumab 靶向肿瘤并通过 IL-2 应答性免疫细胞刺激抗肿瘤免疫反应,以及通过其 Fc 受体刺激免疫细胞[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Tucotuzumab (75 μg; 瘤内注射; 每日 5 次,每次15 μg (总剂量 75 μg),各用50 μL PBS; 在第 10 天和第 14 天),肿瘤生长抑制显著增强,生存率提高[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice bearing CT26-KS colon adenocarcinoma[1]
Dosage: 75 μg
Administration: Intratumoral injection; 5 daily of 15 μg (total dose of 75 μg), each in 50 μL PBS; on days 10 and 14
Result: Resulted in significantly greater tumor growth suppression and enhanced survival.
Clinical Trial
CAS 号
Unlabeled CAS

性状

液体

颜色

Colorless to light yellow

中文名称

西莫白介素单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: ≥95.0%

参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tucotuzumab
目录号:
HY-P99328
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