2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. TUG-905

TUG-905 是一种有效的 GPR40 激动剂，pEC50 值为 7.03。TUG-905 促进下丘脑细胞增殖和存活。TUG-905 减轻体重并增加 POMC mRNA 表达。

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TUG-905 Chemical Structure

TUG-905 Chemical Structure

CAS No. : 1390641-90-3

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Customer Review

TUG-905 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].

IC50 & Target

pEC50: 7.03 (GPR40)[1]
体外研究
(In Vitro)

TUG-905 (10 µM；7、13 天) 促进细胞增殖和增加神经母细胞标记物 DCX mRNA 水平[2]。
TUG-905 (10 µM；2、4、24 小时) 增加 Neuro2a (鼠神经母细胞瘤) 细胞中的 GPR40、BDNF 基因表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TUG-905 相关抗体:

Western Blot Analysis[2]

Cell Line: DCX/GFAP positive cells (neurospheres from mouse hypothalamic tissue)
Concentration: 10 µM
Incubation Time: 7 days
Result: Increased mRNA levels of the neuroblast marker, DCX, as well as the number of DCX-immunopositive cells.
体内研究
(In Vivo)

TUG-905 (2.0 μL，1.0 mM；i.c.v.；每天两次，持续 6 天) 可降低体重并表现出减少热量摄入的趋势[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, Male Swiss mice[1]
Dosage: 2.0 μL, 1.0 mM
Administration: I.c.v.; twice a day for 6 days
Result: Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression.
分子量

499.59

Formula

C27H30FNO5S
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TUG-905 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TUG-9051390641-90-3TUG905TUG 905Free Fatty Acid ReceptorFFARproliferationhypothalamic cellbody massPOMCDCXInhibitorinhibitorinhibit

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产品名称：
TUG-905
目录号：
HY-117787
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