2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. Upadacitinib tartrate tetrahydrate

Upadacitinib tartrate tetrahydrate  (Synonyms: ABT-494 tartrate tetrahydrate)

目录号: HY-19569A
产品使用指南

摩尔计算器

Upadacitinib (ABT-494) tartrate tetrahydrate 是一种高效的、具有口服活性的、选择性 Janus 激酶 1 (JAK1) 抑制剂 (IC50=43 nM)。Upadacitinib tartrate tetrahydrate 对 JAK1 的选择性约为 JAK2 (200 nM）的 74 倍。Upadacitinib tartrate tetrahydrate 可用于多种自身免疫性疾病的研究。

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Upadacitinib tartrate tetrahydrate Chemical Structure

Upadacitinib tartrate tetrahydrate Chemical Structure

CAS No. : 1607431-21-9

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Upadacitinib tartrate tetrahydrate 的其他形式现货产品:

Customer Review

Other Forms of Upadacitinib tartrate tetrahydrate:

Upadacitinib tartrate tetrahydrate 相关抗体

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查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research[1][2].

IC50 & Target[1]

JAK1

0.043 μM (IC50)

JAK2

0.2 μM (IC50)

JAK3

2.3 μM (IC50)

Tyk2

4.7 μM (IC50)

体外研究
(In Vitro)

In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Upadacitinib tartrate tetrahydrate 相关抗体:
体内研究
(In Vivo)

Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rats (Rat adjuvant-induced arthritis model)[3]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: Oral gavage; twice a day for 10 days
Result: Inhibited disease pathology in rat adjuvant induced arthritis.
Clinical Trial
分子量

602.52

Formula

C17H19F3N6O.C4H6O6.4H2O
CAS 号
中文名称

乌帕替尼四水酒石酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Upadacitinib tartrate tetrahydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Upadacitinib tartrate tetrahydrate1607431-21-9ABT-494 tartrate tetrahydrate乌帕替尼四水酒石酸盐JAKJanus kinaseInhibitorinhibitorinhibit

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