2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR2-IN-1

VEGFR2-IN-1 是一种有效的选择性 VEGFR2 抑制剂 (IC50=19.8 nM)。VEGFR2-IN-1 通过凋亡激活和抑制 VEGFR2 的表达来抑制细胞的增殖和迁移。

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VEGFR2-IN-1 Chemical Structure

VEGFR2-IN-1 Chemical Structure

CAS No. : 2765224-55-1

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VEGFR2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR2-IN-1 is a potent and selective VEGFR2 inhibitor (IC50=19.8 nM). VEGFR2-IN-1 inhibits cell proliferation and migration through apoptosis activation and VEGFR2 inhibition[1].

IC50 & Target

VEGFR2

19.8 nM (IC50)

体外研究
(In Vitro)

VEGFR2-IN-1 (compound 17; 0.1, 1, 10, 100 μM; 48 hours) shows an effective and selective agent against MCF-7 (IC50=1.18 μM), MDA-MB-231 (IC50=10.49 μM), MCF-10A (IC50=24.76 μM) cells[1]. VEGFR2-IN-1 (MCF-7 cells; 48 hours) induces cell cycle arrest at the G1 and S-phases[1]. VEGFR2-IN-1 (MCF-7 cells) shows the upregulation of pro-apoptotic genes (p53, Bax, caspases-3, caspases-9) and downregulation of antiapoptotic gene (Bcl-2)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR2-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7, MDA-MB-231, MCF-10A cells
Concentration: 0.1, 1, 10, 100 μM
Incubation Time: 48 hours
Result: Exhibited an effective and selective agent against MCF-7 (IC50=1.18 μM), MDA-MB-231 (IC50=10.49 μM), MCF-10A (IC50=24.76 μM) cells.
体内研究
(In Vivo)

VEGFR2-IN-1 (4.2 mg/kg; i.p.; once a day for 7 days) shows anticancer activity with an improvement of hematological, biochemical parameters[1]. Animal Model: Male Swiss albino mice, 21-28 g (Xenograft model)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice, 21-28 g (Xenograft model)[1]
Dosage: 4.2 mg/kg
Administration: i.p.; once a days; 7 days
Result: Showed anticancer activity by having a tumor inhibition ratio of 54.2% with an improvement of hematological, biochemical parameters.
分子量

398.48

Formula

C22H18N6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR2-IN-12765224-55-1VEGFRVascular endothelial growth factor receptoranticancerapoptosisXenograft modelMCF-7 cellsG1 and S-phasesbreast cancerInhibitorinhibitorinhibit

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目录号：
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