2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. WNK-IN-11-d3

WNK-IN-11-d3 是一种具有口服活性、选择性和强效的 With-No-Lysine (WNK) 激酶抑制剂。WNK-IN-11-d3 有效调节心血管稳态。

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WNK-IN-11-d<sub>3</sub> Chemical Structure

WNK-IN-11-d3 Chemical Structure

CAS No. : 2123483-49-6

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7500
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50 mg   询价  

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Customer Review

Other Forms of WNK-IN-11-d3:

WNK-IN-11-d3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

IC50 & Target

WNK[1]
体内研究
(In Vivo)

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague−Dawley rats[1]
Dosage: 1.5 mg/kg
Administration: P.o.
Result: Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
Animal Model: FVB mice[1]
Dosage: 30 mg/kg
Administration: P.o.
Result: Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
Animal Model: FVB mice[1]
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
分子量

465.41

Formula

C21H18D3Cl2N5OS
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (214.86 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1486 mL 10.7432 mL 21.4864 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.84%

COA (261 KB) HNMR (134 KB) RP-HPLC (246 KB)

产品使用指南 (1538 KB)
参考文献

WNK-IN-11-d3 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1486 mL 10.7432 mL 21.4864 mL 53.7161 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL 10.7432 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3716 mL
15 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5811 mL
20 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6858 mL
25 mM 0.0859 mL 0.4297 mL 0.8595 mL 2.1486 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
40 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
60 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
80 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
100 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNK-IN-11-d32123483-49-6Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesorallyactiveselectivepotenteffectivecardiovascularhomeostasisInhibitorinhibitorinhibit

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目录号：
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