2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) Pyroptosis
  4. WYJ-2

WYJ-2 是 Toll 样受体 2/1 (TLR2/1) 的选择性激动剂，在人 TLR2 和 TLR1 瞬时共转染的 HEK 293T 细胞中的 EC50 为 18.57 nM。WYJ-2 可诱导细胞焦亡 (pyroptosis)，并对非小细胞肺癌 (NSCLC) 表现出抗癌活性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

WYJ-2 Chemical Structure

WYJ-2 Chemical Structure

CAS No. : 3029403-05-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

WYJ-2 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1) with EC50 of 18.57 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 induces pyroptosis and exhibits anticancer activity against non-small cell lung cancer (NSCLC)[1].

IC50 & Target

TLR2

 

体外研究
(In Vitro)

WYJ-2 (0-10 μM) 抑制 THP-1 细胞中 TLR2 和 TLR1 异二聚化，刺激 MyD88 蛋白，激活 NF-κB 信号通路，且无明显细胞毒性[1]。
WYJ-2 (0-100 μM) 抑制癌细胞 A549、HeLa、HepG2 和 MCF-7 增殖，IC50 约为 10 μM，诱导癌细胞通过激活 NLRP3 炎性体而发生细胞焦亡 (pyroptosis)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WYJ-2 相关抗体:

Western Blot Analysis[1]

Cell Line: PAM-differentiated THP-1
Concentration: 0-10 μM
Incubation Time: 12 h
Result: Upregulated levels of MyD88, p-p65, TLR1 and TLR2.
Increased NLRP3.

Immunofluorescence[1]

Cell Line: PAM-differentiated THP-1
Concentration: 0-10 μM
Incubation Time: 12 h
Result: Induced translocation of p-p65 in nucleus.
体内研究
(In Vivo)

WYJ-2 (5 mg/kg，腹腔注射，每 2 天一次，共 30 天) 可抑制 A549 异种移植 BALB/c 小鼠的肿瘤生长，且无明显毒性[1]。
WYJ-2 (10 mg/kg，腹腔注射，单剂量) 在 BALB/c 小鼠体内半衰期 T1/2 为 3.67 小时，清除率 Cmax 为 497 ± 49 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 xenograft BALB/c mice[1]
Dosage: 5 mg/kg
Administration: i.p. every two days for 30 days
Result: Inhibited tumor growth with a TGI of 72.22% without significant loss of body weight.
分子量

357.27

Formula

C17H9F2N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WYJ-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WYJ-23029403-05-9WYJ2WYJ 2Toll-like Receptor (TLR)PyroptosisToll-like receptorBALB/c miceHeLaA549HepG2MCF7cervical carcinoma cell line,lung carcinomahepatoma carcinomabreast carcinomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
WYJ-2
目录号：
HY-158058
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z