CLEC4E - C-type lectin domain family 4 member E Gene

中文名称：C 型凝集素结构域家族 4 成员 E

种属: Homo sapiens

同用名: MINCLE; CLECSF9

基因 ID: 26253 | 基因类型: protein coding

关于 CLEC4E

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,533,305-8,540,905 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 14 paralogues. Biased expression in appendix (RPKM 10.3), spleen (RPKM 8.6) and 11 other tissues.

功能概要

该基因编码 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。该家族的成员具有共同的蛋白质折叠并具有多种功能，例如细胞粘附、细胞间信号传导、糖蛋白转换以及在炎症和免疫反应中的作用。编码的 II 型跨膜蛋白是 CCAAT/增强子结合蛋白 (C/EBP) 、β (CEBPB) 的下游靶标，可能在炎症中发挥作用。已经描述了替代剪接变体，但尚未确定它们的全长序列。该基因与自然杀伤基因复合区 12p13 染色体上的其他 CTL/CTLD 超家族成员密切相关。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4E 基因产物(2)

mRNA	Protein	Name
NM_001410969.1	NP_001397898.1	C-type lectin domain family 4 member E isoform 2
NM_014358.4	NP_055173.1	C-type lectin domain family 4 member E isoform 1

CLEC4E 蛋白结构

Lectin_C

0
100
200
219 a.a.

蛋白主名

其他名称

C-type lectin domain family 4 member E

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9

重组 CLEC4E 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70118	CLEC4E Protein, Human (HEK293, His)	Q9ULY5 (R41-L219)	≥95%

关联疾病

疾病名称

别名

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Tinea Corporis

Dermatophytosis Of The Body

Dermatophytosis Of The Trunk

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Candidal Paronychia

Candidiasis Of Skin	Candidiasis Of Skin And Nails
Candidal Perionyxis

Fungal Infectious Disease

Mycoses

Mycosis

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Primary Systemic Mycosis

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Invasive Aspergillosis

Aspergillosis Invasive

Common Wart

Verruca Vulgaris	Viral Warts Nos
Filiform Warts	Digitate Warts

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

Tinea Pedis

Athlete'S Foot	Dermatophytosis Of Foot
Ringworm Of Foot	Moccasin Foot

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02794	CLEC4E Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CLEC4E	MGD	MGI:1861232
Bos taurus	CLEC4E	VGNC	VGNC:27432
Macaca mulatta	CLEC4E	VGNC	VGNC:99916
Rattus norvegicus	CLEC4E	RGD	RGD:1359298
Others	CLEC4E	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

CLEC4E - C-type lectin domain family 4 member E Gene

关于 CLEC4E

功能概要

CLEC4E 基因产物(2)

CLEC4E 蛋白结构

重组 CLEC4E 蛋白

关联疾病

直系同源

热门区域

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CLEC4E - C-type lectin domain family 4 member E Gene

关于 CLEC4E

功能概要

CLEC4E 基因产物(2)

CLEC4E 蛋白结构

重组 CLEC4E 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z