Animal-Free 4-1BBL/TNFSF9 蛋白, Human (His)

4-1BBL/TNFSF9 protein is a cytokine that selectively binds to TNFRSF9 and exerts its effects by inducing the proliferation of activated peripheral blood T cells. As a homotrimer, this ligand demonstrates its potential role in activation-induced cell death (AICD) and may be involved in coordinating homologous interactions between T cells and B cells/macrophages. Animal-Free 4-1BBL/TNFSF9 Protein, Human (His) is the recombinant human-derived animal-Free4-1BBL/TNFSF9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free 4-1BBL/TNFSF9 Protein, Human (His) is 185 a.a., with molecular weight of ~20.38 kDa.

4-1BBL (TNFSF9) 蛋白是一种具有显着免疫调节功能的细胞因子，与 TNFRSF9 受体结合。其相互作用可诱导活化的外周血 T 细胞增殖，表明其在 T 细胞活化和免疫反应放大中发挥作用。此外，4-1BBL 可能参与激活诱导的细胞死亡 (AICD)，这是一个调节激活免疫细胞的存活和稳态的过程。此外，该蛋白质可能在介导 T 细胞和 B 细胞/巨噬细胞之间的同源相互作用中发挥作用，有助于免疫细胞的通讯和协调。在结构上，4-1BBL 形成同源三聚体，表明其组织成三聚体复合物。这些不同的功能强调了 4-1BBL 在免疫调节和免疫系统内细胞间通讯中的关键作用。

Measure by its ability to induce IL-8 secretion in human PBMCs. The ED₅₀ for this effect is 1-5 ng/mL

Human

E. coli

C-His

P41273 (M70-EE254)

8744  [NCBI]

MREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE

Approximately 20.38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.