C6/Complement component C6 蛋白, Human (HEK293, His)

C6/Complement component C6 Protein is a part of the lytic membrane attack complex formed during complement activation, which has an indispensable role in innate and acquired immune responses by forming pores in the plasma membrane of target cells, as well as cancer immune surveillance. It is a component of the complement cascade which can be incorporated into the cell membrane and cause cell lysis. People with C6 deficiency are prone to bacterial infection. C6/Complement component C6 Protein, Human (HEK293, His) is the recombinant human-derived C6/Complement component C6 protein, expressed by HEK293 , with C-His labeled tag. The total length of C6/Complement component C6 Protein, Human (HEK293, His) is 934 a.a., with molecular weight of ~110 kDa.

补体成分C6 (C6) 是补体激活过程中形成的裂解膜攻击复合物的一部分，通过在靶细胞质膜上形成孔，在先天性和获得性免疫反应以及癌症免疫监视中发挥着不可或缺的作用。它是补体级联的一个组成成分，可以融入细胞膜并引起细胞裂解。纯化的人 C6 是末端补体途径所特有的，并且在炎症反应中也发挥着关键作用。C6 缺乏症是最常见的终末补体成分缺乏症，可在年龄较大时出现脑膜炎奈瑟菌感染^[1][2]。

Human

HEK293

C-His

AAA59668 (M1-A934)

729  [NCBI]

Approximately 110 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.