2. 重组蛋白
  3. Immune Checkpoint Proteins Receptor Proteins
  4. Stimulatory Immune Checkpoint Molecules
  5. CD200R
  6. CD200R1
  7. CD200R1 蛋白, Mouse (HEK293, His-Fc)

CD200R1 蛋白, Mouse (HEK293, His-Fc)

目录号: HY-P75624
产品使用指南

CD200R1 蛋白通过与 CD200/OX2 细胞表面糖蛋白结合并抑制促炎分子表达来抑制炎症反应。CD200R1 通过其 N 端 Ig 样结构域与 CD200 相互作用，为其调节炎症的作用提供了分子机制。CD200R1 蛋白, Mouse (HEK293, His-Fc) 是重组的 CD200R1 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。CD200R1 蛋白, Mouse (HEK293, His-Fc) 全长 213 个氨基酸，分子量为 90-100 kDa。

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3.  试用装只面向终端客户。

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100 μg   询价  

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描述

CD200R1 protein inhibits inflammatory responses by binding to CD200/OX2 cell surface glycoprotein and suppressing pro-inflammatory molecule expression. CD200R1 interacts with CD200 through their N-terminal Ig-like domains, providing a molecular mechanism for its role in regulating inflammation. CD200R1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived CD200R1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of CD200R1 Protein, Mouse (HEK293, His-Fc) is 213 a.a., with molecular weight of 90-100 kDa.
研究背景

CD200R1 蛋白作为 CD200/OX2 细胞表面糖蛋白的抑制性受体，在调节炎症反应中发挥关键作用。其抑制作用表现为响应特定刺激而抑制促炎分子的表达，例如 TNF-α、干扰素和诱导型一氧化氮合酶 (iNOS)。CD200 和 CD200R1 之间的相互作用是通过它们各自的 N 端 Ig 样结构域介导的，突显了该受体有助于调节炎症过程的关键分子机制。
种属

Mouse
表达系统

HEK293
标签

C-hFc;C-His
蛋白编号

Q9ES57/NP_067300.1 (T26-P238)
基因 ID

57781  [NCBI]
蛋白结构
N-term
CD200R1 (T26-P238)
Accession # Q9ES57/NP_067300.1
hFc-His
C-term
同用名
Cell surface glycoprotein CD200 receptor 1; CD200R; CRTR2; MOX2R; OX2R
分子量

90-100 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD200R1 Protein, Mouse (HEK293, His-Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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