CD43 蛋白, Mouse (HEK293, His)

CD43, Mouse, a predominant leukocyte surface sialoprotein, crucially regulates T-cell functions. It positively influences T-cell activation, proliferation, differentiation, trafficking, and migration, especially enhancing migration to lymph nodes through ERM proteins. CD43, Mouse, negatively steers Th2 differentiation, promotes Th1 lineage commitment, and induces IFN-gamma expression during TCR activation in CD4(+) and CD8(+) T-cells. Facilitating Th17 cell rolling, CD43, Mouse, serves as a major E-selectin ligand, mediates Th17 cell adhesion to E-selectin, acts as a T-cell counter-receptor for SIGLEC1, and protects against apoptotic signals, promoting cell survival. CD43 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD43 protein, expressed by HEK293, with C-His labeled tag. The total length of CD43 Protein, Mouse (HEK293, His) is 229 a.a., with molecular weight of 80-120 kDa.

小鼠体内的 CD43 蛋白是白细胞的主要细胞表面唾液酸蛋白，对免疫反应至关重要的各种 T 细胞功能发挥调节作用。CD43 积极调节 T 细胞活化、增殖、分化、运输和迁移，特别是通过与 ERM 蛋白（EZR、RDX 和 MSN）相互作用增强 T 细胞向淋巴结的运输。除了负向调节 Th2 细胞分化外，CD43 还引导 T 细胞向 Th1 谱系定向发展。它在 T 细胞受体 (TCR) 激活过程中诱导 IFN-γ 表达发挥关键作用，影响 CD4(+) 和 CD8(+) T 细胞，并有助于 T 细胞准备细胞因子感应和分化通过影响细胞因子受体 IFNGR 和 IL4R 的表达进入效应细胞。作为主要的 E-选择素配体，CD43 促进 Th17 细胞在激活的脉管系统上滚动，并随后在炎症过程中募集，介导 Th17 细胞与 E-选择素的粘附。此外，CD43 作为 SIGLEC1 的 T 细胞反受体，通过屏蔽细胞免受凋亡信号的影响而发挥保护作用，从而促进细胞存活。

Mouse

HEK293

C-His

P15702 (D20-G248)

20737  [NCBI]

80-120 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.