GM-CSF 蛋白, Bovine (P. pastoris, His-Myc)

The GM-CSF protein is a key cytokine that fundamentally stimulates the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. As a monomer, GM-CSF interacts with the GM-CSF receptor complex to form a dodecamer, which contains two α, two β, and two head-to-head hexamers of the ligand subunits. GM-CSF Protein, Bovine (P. pastoris, His-Myc) is the recombinant bovine-derived GM-CSF protein, expressed by P. pastoris , with C-Myc, C-6*His labeled tag. The total length of GM-CSF Protein, Bovine (P. pastoris, His-Myc) is 126 a.a., with molecular weight of 18 kDa.

GM-CSF 蛋白是一种关键细胞因子，在刺激不同谱系的造血前体细胞（包括粒细胞、巨噬细胞、嗜酸性粒细胞和红细胞）的生长和分化中发挥着重要作用。GM-CSF 作为单体存在，通过 GM-CSF 受体复合物发挥其生物效应，该受体复合物形成十二聚体，该十二聚体包含两个 α、两个 β 和两个配体亚基的两个头对头六聚体。这种复杂的受体复合物强调了 GM-CSF 在协调对造血和免疫功能至关重要的细胞反应方面的多面性。

Bovine

P. pastoris

C-Myc;C-6*His

P11052 (A18-K143)

281095  [NCBI]

APTRPPNTATRPWQHVDAIKEALSLLNHSSDTDAVMNDTEVVSEKFDSQEPTCLQTRLKLYKNGLQGSLTSLMGSLTMMATHYEKHCPPTPETSCGTQFISFKNFKEDLKEFLFIIPFDCWEPAQK

18 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.