DDR2 蛋白, Mouse (HEK293, His)

The DDR2 protein is a tyrosine kinase and cell surface receptor for fibrillar collagen that critically regulates cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is crucial for bone development. It affects osteoblast differentiation and chondrocyte maturation through the MAP kinase signaling pathway and activates the transcription factor RUNX2. DDR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DDR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DDR2 Protein, Mouse (HEK293, His) is 376 a.a., with molecular weight of 60-75 kDa.

DDR2 蛋白作为酪氨酸激酶，作为纤维胶原的细胞表面受体，在调节细胞分化、细胞外基质重塑、细胞迁移和细胞增殖中发挥关键作用。它的作用对于正常骨骼发育至关重要，通过涉及 MAP 激酶的信号通路影响成骨细胞分化和软骨细胞成熟，最终激活转录因子 RUNX2。DDR2还通过上调胶原酶MMP1、MMP2和MMP13，促进细胞迁移和促进肿瘤细胞侵袭，在细胞外基质重塑中发挥重要作用。此外，DDR2 促进成纤维细胞迁移和增殖，对皮肤伤口愈合过程做出显着贡献。DDR2 的多方面功能强调了它在与组织发育、维护和修复相关的多种细胞过程中的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-6*His

Q62371 (Q24-R399)

18214  [NCBI]

QVNPAICRYPLGMSGGHIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVQPDDLKEFLQIDLRTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGSRWISWRNRHGKQVLDGNSNPYDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPTAVYFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSGALPTSPMAPTTYDPMLKVDDSNTR

60-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.