PVR/CD155 蛋白, Rat (HEK293, His)

The PVR/CD155 protein, encoded by the PVR gene, acts as a receptor for poliovirus. It is involved in the regulation of heterophilic and homophilic cell adhesion, as well as leukocyte-mediated cytotoxicity. PVR/CD155 Protein, Rat (HEK293, His) is the recombinant rat-derived PVR/CD155 protein, expressed by HEK293 , with C-His labeled tag. The total length of PVR/CD155 Protein, Rat (HEK293, His) is 319 a.a., with molecular weight of ~54 -75 kDa.

PVR 基因编码脊髓灰质炎病毒受体 (PVR)，也称为 CD155，具有病毒受体的功能。预计 PVR 参与通过质膜细胞粘附分子的异嗜细胞粘附、通过质膜粘附分子的同嗜细胞粘附以及白细胞介导的细胞毒性的正调节。预计它会在细胞迁移和细胞间粘附等过程的上游或内部发挥作用，并预计位于细胞表面和质膜中，作为膜的组成部分，在粘附连接中具有活性。人类的直系同源对应物是 PVR（PVR 细胞粘附分子）。PVR/CD155 在肺 (RPKM 65.2)、心脏 (RPKM 42.8) 和其他九种组织中观察到偏向表达，因此在介导细胞粘附和潜在影响免疫反应方面发挥着至关重要的作用。

Measured by its binding ability in a functional ELISA. Immobilized rat PVR/CD155 at 20 μg/mL (100 μL/well) can bind Rat DNAM-1/CD226. The ED₅₀ for this effect is 796.7 ng/mL.

• 
  Measured by its binding ability in a functional ELISA. Immobilized rat PVR/CD155 at 20 μg/mL (100 μL/well) can bind Rat DNAM-1/CD226. The ED₅₀ for this effect is 796.7 ng/mL.

Rat

HEK293

C-His

NP_058772 (E34-G352)

25066  [NCBI]

EIAVQVLSNSTGFLGGSTVLHCSLASKDNVTITQLTWMKRDPDGSHPSVAVFHPKKGPSISDPERVKFLVAKVYEDLRNASLAISNLRVEDEGIYECQIATFPTGSKSANVWLKVFARPKNTAEALEPSPTLMPQDVAKCISADGHPPGRITWSSNVNGSYREMKETGSQPGTTTVISYLSMVPSSQADGTNITCTVEHESFQEPDQQPLILSLPYPPEVSISGYEGNWYIGLTNVNLTCEARSKPPPTNYSWSTATGPLPNSTHFQENGSHLLISTVDDLNNTIFVCKAINALGSGQGQVTILVKEASEILPPKTSLG

Approximately 54 -75 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.