1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. α-Bungarotoxin

α-Bungarotoxin 

目录号: HY-P1264
产品使用指南

α-Bungarotoxin 是烟碱乙酰胆碱受体 (nAChRs) 的竞争性拮抗剂。α-Bungarotoxin 是一种选择性 α7 受体 (α7 receptor) 阻滞剂,IC50 为 1.6 nM。

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Custom Peptide Synthesis

α-Bungarotoxin Chemical Structure

α-Bungarotoxin Chemical Structure

CAS No. : 11032-79-4

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Description

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2].

In Vitro

α-Bungarotoxin binds specifically and with high affinity to the nicotinic acetylcholine receptor and competes with binding of the natural ligand. α-Bungarotoxin (α-BTX), is a potent competitive inhibitors of nicotinic acetylcholine receptor function and is highly toxic due to functional blockade of AcChoRs at the neuromuscular junction[3].

Molecular Weight

7984.12

Formula

C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

CAS No.

11032-79-4

Sequence Shortening

IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG (Disulfide bridge:Cys3-Cys33;Cys16-Cys44;Cys29-Cys33;Cys48-Cys59;Cys60-Cys65)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

α-BungarotoxinnAChRNicotinic acetylcholine receptorsligandionchannelsneurotoxinInhibitorinhibitorinhibit

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产品名称:
α-Bungarotoxin
目录号:
HY-P1264
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