2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. ICI 211965

ICI 211965  (Synonyms: ZM-211965)

目录号: HY-100148
产品使用指南

摩尔计算器

ICI 211965 (ZM-211965) 是一个有选择性且口服有效的 5-脂氧合酶 (5-LPO) 抑制剂。

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ICI 211965 Chemical Structure

ICI 211965 Chemical Structure

CAS No. : 129424-08-4

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ICI 211965 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

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5-LOX 12-LOX 15-LOX

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor.

IC50 & Target

5-LPO

 

体外研究
(In Vitro)

ICI 211965 (ZM-211965) is a selective and orally potent 5-Lipoxygenase (5-LPO) inhibitor. ICI 211965 reduces the leakage of lactate dehydrogenase (LD) and lipid peroxidation at concentrations related to its antioxidative effect and not to its 5-1ipoxygenase-inhibiting effect[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ICI 211965 相关抗体:
分子量

389.51

Formula

C24H23NO2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay

The myocytes are plated on 35 mm plastic culture dishes at a density of approximately 9×105 cells/mL (1.8×106 cells/dish). The cells are kept in culture for 6 d at 37°C and 5% CO2 under aerobic conditions in a carbon dioxide incubator. During this period the cells are beating spontaneously at an approximate frequency of 20 to 40 beats/min. Each culture dish contains 0.9+0.2 mg protein. The antioxidant ICI 211965 is added to the culture medium at a final concentration of 0.1% ethanol. Cell damage is determined by leakage of lactate dehydrogenase (LD) to the medium, and is analyzed after 0.5, 1.0, 2.0, 3.0, and 5.0 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ICI 211965 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 211965129424-08-4ZM-211965ICI211965ICI-211965ZM211965ZM 211965LipoxygenaseLOXInhibitorinhibitorinhibit

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