1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. MGAT2-IN-1

MGAT2-IN-1 

目录号: HY-101857 纯度: 99.49%
产品使用指南

MGAT2-IN-1 是一种可口服的单酰甘油酰基转移酶 (MGAT2) 抑制剂,对人和小鼠 MGAT2 的 IC50 值分别为 7.8 和 2.4 nM。

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MGAT2-IN-1 Chemical Structure

MGAT2-IN-1 Chemical Structure

CAS No. : 1800025-30-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥6475
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5 mg ¥4500
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10 mg ¥7500
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25 mg ¥15000
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50 mg ¥22000
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100 mg ¥35000
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查看 Acyltransferase 亚型特异性产品:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

IC50 & Target

IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)[1]

体内研究
(In Vivo)

MGAT2-IN-1 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. MGAT2-IN-1 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, MGAT2-IN-1 significantly increases free fatty acid (FFA) and acylcarnitine levels. MGAT2-IN-1 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. MGAT2-IN-1 shows anti-diabetic effects in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

654.01

Formula

C27H21ClF5N7O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 125 mg/mL (191.13 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5290 mL 7.6451 mL 15.2903 mL
5 mM 0.3058 mL 1.5290 mL 3.0581 mL
10 mM 0.1529 mL 0.7645 mL 1.5290 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
Animal Administration
[1]

Mice: Overnight-fasted mice undergo MTT in the morning. First, they are orally administered vehicle (0.5% methylcellulose solution) or MGAT2-IN-1 suspended in 0.5% methylcellulose. Six or 16 h after dosing, they are intraperitoneally injected 500 mg/kg Pluronic F-127 to inhibit plasma TG hydrolysis by lipoprotein lipase (LPL). Thirty minutes after injection, the mice are given an oral liquid meal (10 mL/kg) comprising an admixture of corn oil and Ensure-H (3:17 v/v). Blood samples are collected at 0, 2 and 4 h after oral gavage of the liquid meal. Area under the curve (AUC) of chylomicron TG (CM/TG), which is synthesised from dietary fat in the small intestine, is calculated by subtracting plasma TG levels of a liquid meal-untreated group from plasma TG levels of each treated group.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
MGAT2-IN-1
目录号:
HY-101857
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