1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. TP-020

TP-020  (Synonyms: MGAT2-IN-1)

目录号: HY-101857 纯度: 98.96%
COA 产品使用指南

TP-020 (MGAT2-IN-1) 是一种可口服的单酰甘油酰基转移酶 (MGAT2) 抑制剂,对人和小鼠 MGAT2IC50 值分别为 7.8 和 2.4 nM。

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TP-020 Chemical Structure

TP-020 Chemical Structure

CAS No. : 1800025-30-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥6475
In-stock
1 mg ¥2045
In-stock
5 mg ¥4500
In-stock
10 mg ¥7500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

查看 Acyltransferase 亚型特异性产品:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

IC50 & Target

IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)[1]

体内研究
(In Vivo)

TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

654.01

Formula

C27H21ClF5N7O3S

CAS 号
性状

固体

颜色

White to gray

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验: 

DMSO 中的溶解度 : ≥ 125 mg/mL (191.13 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5290 mL 7.6451 mL 15.2903 mL
5 mM 0.3058 mL 1.5290 mL 3.0581 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice: Overnight-fasted mice undergo MTT in the morning. First, they are orally administered vehicle (0.5% methylcellulose solution) or MGAT2-IN-1 suspended in 0.5% methylcellulose. Six or 16 h after dosing, they are intraperitoneally injected 500 mg/kg Pluronic F-127 to inhibit plasma TG hydrolysis by lipoprotein lipase (LPL). Thirty minutes after injection, the mice are given an oral liquid meal (10 mL/kg) comprising an admixture of corn oil and Ensure-H (3:17 v/v). Blood samples are collected at 0, 2 and 4 h after oral gavage of the liquid meal. Area under the curve (AUC) of chylomicron TG (CM/TG), which is synthesised from dietary fat in the small intestine, is calculated by subtracting plasma TG levels of a liquid meal-untreated group from plasma TG levels of each treated group.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5290 mL 7.6451 mL 15.2903 mL 38.2257 mL
5 mM 0.3058 mL 1.5290 mL 3.0581 mL 7.6451 mL
10 mM 0.1529 mL 0.7645 mL 1.5290 mL 3.8226 mL
15 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
20 mM 0.0765 mL 0.3823 mL 0.7645 mL 1.9113 mL
25 mM 0.0612 mL 0.3058 mL 0.6116 mL 1.5290 mL
30 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
40 mM 0.0382 mL 0.1911 mL 0.3823 mL 0.9556 mL
50 mM 0.0306 mL 0.1529 mL 0.3058 mL 0.7645 mL
60 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
80 mM 0.0191 mL 0.0956 mL 0.1911 mL 0.4778 mL
100 mM 0.0153 mL 0.0765 mL 0.1529 mL 0.3823 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
TP-020
目录号:
HY-101857
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