1. GPCR/G Protein
  2. LPL Receptor
  3. Icanbelimod

Icanbelimod  (Synonyms: S1p receptor agonist 1)

目录号: HY-101265 纯度: 99.95%
COA 产品使用指南

Icanbelimod (S1p receptor agonist 1) 是一种有效的口服活性 S1P receptor 激动剂,具有诱导 S1P1 内化的活性 (EC50=9.83 nM)。Icanbelimod 有潜力用于研究关节炎和 EAE (实验性自身免疫性脑炎) 的相关研究。Icanbelimod 是专利 WO2015039587A1 中的化合物 2。

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Icanbelimod Chemical Structure

Icanbelimod Chemical Structure

CAS No. : 1514888-56-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2200
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1 mg ¥500
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5 mg ¥2000
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10 mg ¥3500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.

IC50 & Target

EC50: 9.83 nM (S1P1 internalization)[1]

体内研究
(In Vivo)

Icanbelimod (oral administration; 0.01 mg/kg-1 mg/kg) at all dose is active, and only a dose of 0.01 mg/kg is required to observe a decrease in the number of peripheral blood lymphocytes by more than 50% and a decrease in the 1 mg/kg dose. Besides, this compound is lymphocyte-specific, which dose not significantly alter the number of peripheral monocytes and other white blood cells in SD rats[1].
Icanbelimod (oral administration; 3 mg/kg; 12 days) is has been proved to block lymphocyte efflux. In the development of type II collagen-induced arthritis in rat model, compound 2 is effective in inhibiting the development of joint swelling in arthritis and joint structure destruction[1].
Icanbelimod (oral administration; 0.3-1mg/kg; 30 days; once daily) inhibits the development of experimental autoimmune encephalitis (EAE) as a dose-dependent manner in mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats[1]
Dosage: 3 mg/kg
Administration: Oral administration
Result: Decreased the severity score of arthritis in the four-legged rats.
Animal Model: Female C57BL/6 mice[1] 
Dosage: 0.03, 0.1, and 1 mg/kg
Administration: Oral administration
Result: Decreased the severity score of EAE in MOG 35-55 induced mice.
分子量

409.45

Formula

C23H24FN3O3

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 6.8 mg/mL (16.61 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4423 mL 12.2115 mL 24.4230 mL
5 mM 0.4885 mL 2.4423 mL 4.8846 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Icanbelimod 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4423 mL 12.2115 mL 24.4230 mL 61.0575 mL
5 mM 0.4885 mL 2.4423 mL 4.8846 mL 12.2115 mL
10 mM 0.2442 mL 1.2212 mL 2.4423 mL 6.1058 mL
15 mM 0.1628 mL 0.8141 mL 1.6282 mL 4.0705 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Icanbelimod
目录号:
HY-101265
需求量: