1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Dopamine β-hydroxylase

Dopamine β-hydroxylase

Dopamine β-hydroxylase (Dopamine beta-hydroxylase, Dopamine beta-monooxygenase) is an enzyme that in humans is encoded by the DBH gene. Dopamine β-monooxygenase catalyzes the chemical reaction with 3 substrates of 3,4-dihydroxyphenethylamine, ascorbate, and O2, whereas its 3 products are noradrenaline, dehydroascorbate, and H2O. Dopamine β-hydroxylase belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Dopamine β-hydroxylase participates in tyrosine metabolism. Dopamine β-hydroxylase has 3 cofactors: copper, PQQ, and Fumarate. Dopamine β-hydroxylase is in the catecholamine biosynthetic pathway. Dopamine β-hydroxylase has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.

Dopamine β-hydroxylase 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-13289A
    Nepicastat hydrochloride Inhibitor 99.98%
    Nepicastat hydrochloride (SYN-117 hydrochloride; RS-25560-197 hydrochloride) 是多巴胺_beta_-羟化酶高效抑制剂,对牛源和人源巴胺_beta_-羟化酶的IC50值分别为8.5和9.0nM。
  • HY-106004
    Zamicastat Inhibitor 99.95%
    Zamicastat (BIA 5-1058) 是 多巴胺 β-羟化酶 (DBH)的抑制剂,可通过血脑屏障引起中枢和周边效应。Zamicastat 也是一种浓度依赖性的双重 P-gpBCRP 抑制剂,IC50 值分别为 73.8 μM 和 17.0 μM。具有降血压作用。
  • HY-13289
    Nepicastat Inhibitor
    Nepicastat (SYN117; RS-25560-197)是多巴胺β羟化酶抑制剂,对牛和人的多巴胺β羟化酶的IC50分别为8.5nM和9.0nM。
  • HY-14838
    Etamicastat Inhibitor
    Etamicastat (BIA 5-453) 是一种有效的,可逆的外周多巴胺-β-羟化酶 (DβH) 抑制剂。
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