Troxacitabine (Synonyms: 曲沙他滨; BCH 4556; L-OddC; SPD 758)

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Data Sheet 产品使用指南

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Troxacitabine是一种具有强效抗肿瘤活性的二氧戊环类似物。

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Troxacitabine Chemical Structure

CAS No. : 145918-75-8

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规格	价格	是否有货
5 mg	￥2800	询问价格 & 货期
10 mg	￥4500	询问价格 & 货期
25 mg	￥8800	询问价格 & 货期

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生物活性
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参考文献

生物活性

Troxacitabine is nucleoside analog with potent anticancer activity.

体外研究
(In Vitro)

Troxacitabine has shown cutotoxicity in cancer cell lines of hepatocellular (HepG2), prostate (PC3, DUI45), non-small cell lung (NCI-H460, NCr-322M) colon (HT29), renal (CAK-l, A498, RXF-393, SNI2-C) and pancreatic origin (Pnac-Ol, MiaPa Ca) with IC₅₀s range from 15-35 μM^[1]^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model^[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

213.19

Formula

C₈H₁₁N₃O₄

CAS 号

145918-75-8

性状

固体

颜色

White to off-white

中文名称

曲沙他滨

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. [Content Brief]

[2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10. [Content Brief]

[3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8. [Content Brief]

Animal Administration ^[3]	Mice^[3] Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. [Content Brief] [2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10. [Content Brief] [3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8. [Content Brief]

Animal Administration
^[3]

Mice^[3]

Troxacitabine is administered i.v. to the animals at doses of 10 and 25 mg/kg on a daily 3 5 regimen. Gemcitabine is used as a positive control. The end points for the study included tumor growth inhibition (TGI), final weight, and the number of partial and complete tumor responses in the animals^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Gourdeau H, et al. Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts. Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. [Content Brief]

[2]. Kadhim SA, et al. Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models. Cancer Res. 1997 Nov 1;57(21):4803-10. [Content Brief]

[3]. Weitman S, et al. The new dioxolane, (-)-2'-deoxy-3'-oxacytidine (BCH-4556, troxacitabine), has activity againstpancreatic human tumor xenografts. Clin Cancer Res. 2000 Apr;6(4):1574-8. [Content Brief]

Troxacitabine 相关分类

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Troxacitabine145918-75-8BCH 4556 L-OddC SPD 758曲沙他滨BCH4556BCH-4556SPD758SPD 758SPD-758Nucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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Troxacitabine (Synonyms: 曲沙他滨; BCH 4556; L-OddC; SPD 758)

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Troxacitabine 相关产品

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实验参考方法

纯度 & 产品资料

参考文献

Troxacitabine 相关分类

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The molarity calculator equation

The dilution calculator equation

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Troxacitabine (Synonyms: 曲沙他滨; BCH 4556; L-OddC; SPD 758)

Customer Review

Troxacitabine 相关抗体

Troxacitabine 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Troxacitabine 相关抗体:

Troxacitabine 相关分类

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The molarity calculator equation

The dilution calculator equation

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