2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Interleukin Related Reactive Oxygen Species (ROS) Ferroptosis
  4. Anti-Mouse IL-1b Antibody (B122)

Anti-Mouse IL-1b Antibody (B122) 

目录号: HY-P99139 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-1b Antibody (B122) 是一种抗小鼠 IL-1b IgG 单克隆抗体。Anti-Mouse IL-1b Antibody (B122) 与 Sulfasalazine (SAS) (HY-14655) 联用可以增强铁死亡 (ferroptosis) 并增加的活性氧水平 (ROS)。Anti-Mouse IL-1b Antibody (B122) 可以通过阻断 IL-1β 信号传导来减少单核细胞浸润和缓解 T 细胞耗竭。Anti-Mouse IL-1b Antibody (B122) 可用于研究癌症和心血管疾病，如口腔鳞状细胞癌 (OSCC)、胶质母细胞瘤 (GBM) 和心力衰竭。

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Anti-Mouse IL-1b Antibody (B122)

Anti-Mouse IL-1b Antibody (B122) Chemical Structure

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Anti-Mouse IL-1b Antibody (B122) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure[1][2][3].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2][3]

IL-1

 

体外研究
(In Vitro)

Anti-Mouse IL-1b Antibody (B122) (50 pM，6-72 小时) 与 Sulfasalazine (SAS) 联用显著抑制多种肿瘤细胞增殖，包括 SCC1，A375 和 MDA-MB231 细胞[1]。
Anti-Mouse IL-1b Antibody (B122) (50 pM，24 小时) 与 SAS 联用降低了 SCC1 细胞中 IL-1β 的水平并增强了的铁死亡标志物的表达[1]。
Anti-Mouse IL-1b Antibody (B122) (50 pM，24 小时) 与 SAS 联用可以增加 SCC1 细胞中活性氧的水平，降低 GSH 的水平[1]。
Anti-Mouse IL-1b Antibody (B122) (50 pM) 与 40 % SAS 条件培养基联合使用可逆转 T 细胞耗竭并改善 T 细胞功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-1b Antibody (B122) 相关抗体:

Cell Viability Assay[1]

Cell Line: SCC1, A375 and MDA-MB231 cells
Concentration: 50 pM, combinated with SAS (800 μM)
Incubation Time: 6, 12, 24, 48 and 72 h
Result: Significantly reduced the cell viability of three types of cells.

RT-PCR[1]

Cell Line: SCC1 cells
Concentration: 50 pM, combinated with SAS (800 μM)
Incubation Time: 24 h
Result: Reduced the level of PTSG2 and IL-1β and increased the level of SLC7A11.

Western Blot Analysis[1]

Cell Line: SCC1 cells
Concentration: 50 pM, combinated with SAS (800 μM)
Incubation Time: 24 h
Result: Reduced the level of PTSG2 and IL-1β and increased the level of SLC7A11.
体内研究
(In Vivo)

Anti-Mouse IL-1b Antibody (B122) (100 μg/kg，肿瘤内注射，每 3 天一次，持续 4 周) 与 SAS 联合显著抑制了患有口腔鳞状细胞癌 (OSCC) 的雄性 Sprague-Dawley (SD) 大鼠的肿瘤发展[1]。
Anti-Mouse IL-1b Antibody (B122) (1 mg，瘤内注射，每天一次，直至终点) 显著延长了 PDGFB 过表达和 p53 沉默的 Ntv-a 小鼠的存活期[2]。
Anti-Mouse IL-1b Antibody (B122) (100 μg，腹腔注射，每周两次，持续 2 周) 对心力衰竭 (HFpEF) C57BL/6J 小鼠的右心室功能和肺血管重塑具有保护作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nitrochin (HY-33354) (20 ppm) induced male Sprague-Dawley (SD) rats (4 weeks)[1]
Dosage: 100 μg/kg, combined with SAS (30 mg/kg)
Administration: Intratumoral injection, once every 3 days for 4 weeks
Result: Caused only 16.6 % of cases to develop into mild invasive cancer, while 66.6 % of the control group had moderate invasive cancer.
Significantly inhibited tumor development with the lowest HE score.
Reduced the expression of SLC7A11 and IL-1β and increased the expression of PTGS2.
Reduced Ki67+ cells.
Animal Model: Ntv-a mice with a PDGFB glioblastoma (GBM) model(8-12 weeks)[2]
Dosage: 1 mg
Administration: Intratumoral injection, once daily, until the endpoint
Result: Significantly prolonged the survival of PDGFB GBM mice (median survival extended from 40 days to 47 days).
Reduced tumor associated macrophage (TAMs) infiltration.
Reduced the expression of T cell exhaustion markers (such as PD-1).
Animal Model: L-NAME (HY-18729) (0.5 g/L) and high-fat diet (60 % lipid) administrated C57BL/6J mice (8 weeks)[3]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), twice weekly, for 2 weeks
Result: Significantly reduced the level of IL-1β in lung tissue.
Reduced elevated right ventricular systolic pressure and pulmonary small vessel muscularization.
Had no significant effect on weight changes and right ventricular end diastolic pressure.
基因 ID

16176  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse IL-1b Antibody (B122) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1b Antibody (B122)Interleukin RelatedReactive Oxygen Species (ROS)FerroptosisILIL-1bferroptosisROSGBMOSCCheart failureInhibitorinhibitorinhibit

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