1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. ARL67156 trisodium salt hydrate

ARL67156 trisodium salt hydrate 

目录号: HY-103265B 纯度: >99.0%
产品使用指南

ARL67156 trisodium salt hydrate 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt hydrate 是弱的竞争性 NTPDase1 (CD39),NTPDase3 和 NPP1 抑制剂,Ki 分别为 11,18 和 12 μM。ARL67156 trisodium salt hydrate 可预防体内主动脉瓣钙化。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

ARL67156 trisodium salt hydrate Chemical Structure

ARL67156 trisodium salt hydrate Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥3500 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of ARL67156 trisodium salt hydrate:

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

ARL67156 trisodium salt hydrate is an inhibitor of ecto-ATPase. ARL67156 trisodium salt hydrate is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively[1]. ARL67156 trisodium salt hydrate prevents in vivo the development of calcific aortic valve disease[2].

IC50 & Target

Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)[1]

In Vitro

ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes[1].

In Vivo

Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg)[3].

Animal Model: C57BL/6 mice[3]
Dosage: 2 mg/kg
Administration: Pre-treated (i.p.) 1  h before administration of FBP (100 mg/kg)
Result: Completely prevented the increase of serum adenosine concentration induced by FBP.
Molecular Weight

884.14

Formula

C₁₅H₂₁Br₂N₅O₁₂P₃.₃Na.₅½H₂O

SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(C(Br)(Br)P(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O)N2C3=NC=NC(N(CC)CC)=C3N=C2.O.[5.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ARL67156 trisodium saltPhosphataseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ARL67156 trisodium salt hydrate
目录号:
HY-103265B
需求量: