1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Atamestane

Atamestane  (Synonyms: 阿他美坦; SH 489)

目录号: HY-13558
产品使用指南

Atamestane (SH 489) 是一种特殊的芳香酶抑制剂,可选择性阻断雄烯二酮和睾酮芳香化产生的雌激素生物合成。Atamestane 竞争性且不可逆地抑制雌激素生物合成。Atamestane 可用于良性前列腺增生 (BPH) 的研究。

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Atamestane Chemical Structure

Atamestane Chemical Structure

CAS No. : 96301-34-7

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  • 生物活性

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  • 参考文献

生物活性

Atamestane (SH 489) is a specific aromatase inhibitor, which selectively blocks the estrogen biosynthesis resulting from the aromatization of androstenedione and testosterone. Atamestane is a competitive and irreversible inhibitor of estrogen biosynthesis. Atamestane can be used for the research of benign prostatic hyperplasia (BPH)[1].

体外研究
(In Vitro)

Atamestane inhibits the growth of Ac-1 cells in vitro with IC50 value of 60.4±17.2 μM. The combination of Toremifene plus Atamestane is better than Toremifene or Atamestane alone in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Ac-1 cells
Concentration: 1, 5, 10, 50, 100, 500, and 1000 μM
Incubation Time: 6 days
Result: The growth of Ac-1 cells was inhibited by Atamestane in a dose dependent manner with IC50 value of 60.4±17.2 μM.
体内研究
(In Vivo)

Atamestane is a selective, pure, and highly effective steroidal aromatase inhibitor, with an excellent safety profile. Atamestane completely antagonizes all the estrogen-induced changes in the prostate. Atamestane leads to a decrease of pregnant mare serum gonadotropin-stimulated ovarian estrogen production, and inhibits androstenedione-induced estrogenic effects such as uterine growth and abortion in rats. Atamestane inhibits estrogen-related negative feedback. Atamestane is highly effective in inhibiting estrogen-induced hyperplastic changes in the fibromuscular stroma of the prostate in androstenedione-treated dogs and monkeys[1].
Atamestane (1 and 3 mg/animal/day; subcutaneously for 3 days) inhibits ovarian estrogen biosynthesis in pregnant mare serum gonadotropin (PMSG)-primed rats[1].
The combination of Toremifene (1000μg/day) plus Atamestane (1000μg/day) is as effective as Toremifene or Tamoxifen (100μg/day) alone but may not provide any additional benefit over Toremifene alone or Tamoxifen alone in ovariectomized female SCID mice bearing Ac-1 xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Infantile female rats, weighing about 50 g[1]
Dosage: 1 and 3 mg/animal/day
Administration: Subcutaneously for 3 days
Result: Resulted in a significant dose-dependent decrease of the pregnant mare serum gonadotropin (PMSG)-induced, elevated serum estrogen concentration.
Animal Model: Ovariectomized female SCID mice bearing Ac-1 xenografts[2]
Dosage: Atamestane (1000 μg/day), or the combination of Toremifene (1000 μg/day) plus Atamestane (1000 μg/day)
Administration: Injected subcutaneously
Result: Caused dose dependent reductions in mean tumor weights. The doses of Toremifene and Atamestane which caused maximum reduction in tumor growth were selected for the combination study.
分子量

298.42

Formula

C20H26O2

CAS 号
中文名称

阿他美坦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
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