2. Protein Tyrosine Kinase/RTK
  3. IGF-1R Insulin Receptor
  4. AZD9362

AZD9362 是一种可逆的、ATP 竞争性且具有口服活性的 胰岛素样生长因子 1 受体 (IGF- 1R ) 和胰岛素受体 (insulin receptor) 抑制剂。AZD9362 对 IGF- 1R 酶的抑制作用，IC50 值为 14 nM。AZD9362 可增强 AZD5363 (HY-15431) 的抗肿瘤效果。AZD9362 可用于癌症研究，如乳腺癌研究。

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AZD9362

AZD9362 Chemical Structure

CAS No. : 1905412-80-7

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AZD9362 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431). AZD9362 can be used for the research of cancer, such as breast cancer[1].

体内研究
(In Vivo)

AZD9362 (25 mg/kg，口服) 增强了 AZD5363 (HY-15431) 在 MCF-7/LTED 细胞以及去卵巢且未补充雌激素的小鼠的 MCF-7 异种移植物中的抗肿瘤效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

494.98

Formula

C24H27ClN8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZD9362 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD93621905412-80-7AZD 9362AZD-9362IGF-1RInsulin ReceptorInsulin-like growth factor-1 receptorinsulin receptorAZD5363anti-tumorbreast cancerInhibitorinhibitorinhibit

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目录号：
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