1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. Azido-PEG3-maleimide

Azido-PEG3-maleimide 

目录号: HY-140811
产品使用指南

Azido-PEG3-maleimide 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。Azido-PEG3-maleimide 也是一种可降解 (cleavable) 的含 3 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

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Azido-PEG3-maleimide Chemical Structure

Azido-PEG3-maleimide Chemical Structure

CAS No. : 1858264-36-4

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Description

Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1][2]

PEGs

 

Cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Molecular Weight

369.37

Formula

C₁₅H₂₃N₅O₆

CAS No.

1858264-36-4

SMILES

O=C(NCCOCCOCCOCCN=[N+]=[N-])CCN1C(C=CC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Azido-PEG3-maleimidePROTAC LinkerADC LinkerAntibody-drug conjugates linkerPEGADClinkerPROTACcleavableInhibitorinhibitorinhibit

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产品名称:
Azido-PEG3-maleimide
目录号:
HY-140811
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