1. Anti-infection
  2. HBV
  3. BA-53038B

BA-53038B 是一种 HBV 核心蛋白变构调节剂 (CpAM),与 HAP 口袋结合并调节 HBV 衣壳组装。BA-53038B 对乙型肝炎病毒 (HBV) 具有抗病毒活性,EC50 值为 3.32 μM。BA-53038B 可用于慢性乙型肝炎的研究。

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BA-53038B Chemical Structure

BA-53038B Chemical Structure

CAS No. : 2306195-65-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2200
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5 mg ¥2000
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10 mg ¥3200
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25 mg ¥6400
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50 mg ¥9800
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B[1].

IC50 & Target

EC 50: 3.32 μM (HBV)[1]

体外研究
(In Vitro)

BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM[1].
BA-53038B has cytotoxicity with CC50 value of >100 μM[1].
BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein[1].
BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly[1].
BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein[1].
BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket[1].
BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: AML12HBV10 cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Reduced the amount of hypophosphorylated core protein and promoted the assembly of empty capsids with slow electrophoresis mobility.

RT-PCR[1]

Cell Line: AML12HBV10 and HepDES19 cells
Concentration: 0-20 μM
Incubation Time: 2 or 6 days
Result: Inhibited HBV replication in both AML12HBV10 and HepDES19 cells.
分子量

249.74

Formula

C14H16ClNO

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (1001.04 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0042 mL 20.0208 mL 40.0416 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BA-53038B 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0042 mL 20.0208 mL 40.0416 mL 100.1041 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL 20.0208 mL
10 mM 0.4004 mL 2.0021 mL 4.0042 mL 10.0104 mL
15 mM 0.2669 mL 1.3347 mL 2.6694 mL 6.6736 mL
20 mM 0.2002 mL 1.0010 mL 2.0021 mL 5.0052 mL
25 mM 0.1602 mL 0.8008 mL 1.6017 mL 4.0042 mL
30 mM 0.1335 mL 0.6674 mL 1.3347 mL 3.3368 mL
40 mM 0.1001 mL 0.5005 mL 1.0010 mL 2.5026 mL
50 mM 0.0801 mL 0.4004 mL 0.8008 mL 2.0021 mL
60 mM 0.0667 mL 0.3337 mL 0.6674 mL 1.6684 mL
80 mM 0.0501 mL 0.2503 mL 0.5005 mL 1.2513 mL
100 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0010 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BA-53038B
目录号:
HY-114314
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