2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. MRL-650

MRL-650  (Synonyms: CB1 inverse agonist 1)

目录号: HY-135280
产品使用指南

摩尔计算器

MRL-650 (CB1 inverse agonist 1) 是一种高效的，具有口服活性的，特异性 CB1 受体的反向激动剂，对 CB1 和 CB2 受体的 IC50 分别为 7.5 nM 和 4100 nM。具有抑制食欲作用。

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MRL-650 Chemical Structure

MRL-650 Chemical Structure

CAS No. : 852315-00-5

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规格 价格 是否有货 数量
1 mg ￥2207
1 周
5 mg   询价  
10 mg   询价  

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MRL-650 相关抗体

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects[1].

IC50 & Target[1]

CB1

7.5 nM (IC50)

CB2

4100 nM (IC50)

体内研究
(In Vivo)

MRL-650 (Compound 14; 0.3, 1, or 3 mg/kg）inhibits feeding in a dose-dependent manner[1].
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 0.3, 1, or 3 mg/kg
Administration: PO
Result: Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
分子量

514.79

Formula

C25H18Cl3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRL-650 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRL-650852315-00-5CB1 inverse agonist 1MRL650MRL 650Cannabinoid ReceptorCannabinoidCB1InverseagonistAnorexigenicObesityInhibitorinhibitorinhibit

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