2. GPCR/G Protein Neuronal Signaling NF-κB Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR
  3. mGluR NF-κB ERK Akt
  4. CHPG

CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。

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CHPG Chemical Structure

CHPG Chemical Structure

CAS No. : 170846-74-9

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规格 价格 是否有货 数量
1 mg ￥1636
In-stock
5 mg ￥3600
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Customer Review

Other Forms of CHPG:

CHPG 相关抗体

Top Publications Citing Use of Products

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ERK ERK1 ERK2 ERK5 ERK8

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].

IC50 & Target

mGlu5

 

NF-κB

 

ERK

 

体外研究
(In Vitro)

CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHPG 相关抗体:

Cell Viability Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10, 50, 100 and 500 µM
Incubation Time: 24 hours
Result: Increased the cell viability.

Apoptosis Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Protected BV2 cells against SO2-induced apoptosis.

Western Blot Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Increased the expression of TSG-6 in both mRNA and protein levels.
体内研究
(In Vivo)

CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g[2]
Dosage: 250 nM
Administration: Injection; for 7 days
Result: Reduced significantly cerebral lesion volume.
分子量

201.61

Formula

C8H8ClNO3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

1M NaOH 中的溶解度 : 25 mg/mL (124.00 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9601 mL 24.8004 mL 49.6007 mL
5 mM 0.9920 mL 4.9601 mL 9.9201 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (262 KB)

产品使用指南 (1538 KB)
参考文献

CHPG 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
1M NaOH 1 mM 4.9601 mL 24.8004 mL 49.6007 mL 124.0018 mL
5 mM 0.9920 mL 4.9601 mL 9.9201 mL 24.8004 mL
10 mM 0.4960 mL 2.4800 mL 4.9601 mL 12.4002 mL
15 mM 0.3307 mL 1.6534 mL 3.3067 mL 8.2668 mL
20 mM 0.2480 mL 1.2400 mL 2.4800 mL 6.2001 mL
25 mM 0.1984 mL 0.9920 mL 1.9840 mL 4.9601 mL
30 mM 0.1653 mL 0.8267 mL 1.6534 mL 4.1334 mL
40 mM 0.1240 mL 0.6200 mL 1.2400 mL 3.1000 mL
50 mM 0.0992 mL 0.4960 mL 0.9920 mL 2.4800 mL
60 mM 0.0827 mL 0.4133 mL 0.8267 mL 2.0667 mL
80 mM 0.0620 mL 0.3100 mL 0.6200 mL 1.5500 mL
100 mM 0.0496 mL 0.2480 mL 0.4960 mL 1.2400 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHPG170846-74-9mGluRNF-κBERKAktMetabotropic glutamate receptorsNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesPKBProtein kinase BInhibitorinhibitorinhibit

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