2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Chrexanthomycin C

Chrexanthomycin C 是一种具有显著生物活性的海洋天然产物，具有口服活性。Chrexanthomycin C 对 DNA (G4C2)4 G4 具有结合亲和力，Kd 值为 2.8 mM。Chrexanthomycin C 可用于肌萎缩侧索硬化症 (ALS) 等神经退行性疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Chrexanthomycin C Chemical Structure

Chrexanthomycin C Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Chrexanthomycin C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2)4 G4 with a Kd value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)[1].

IC50 & Target

Kd: 2.8 mM (DNA (G4C2)4 G4)[1]
体外研究
(In Vitro)

Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)4 G4 with a Kd value of 2.8 mM[1].
Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity[1].
Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells[1].
Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s[1].
Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chrexanthomycin C 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 0.16, 1.57 and 15.67 μM
Incubation Time: 24 h
Result: Showed no cytotoxicity up to the concentration of 10 μg/mL.
体内研究
(In Vivo)

Chrexanthomycin C (Compounds cC) (fed; 100 μM) significantly rescues eye degeneration and improve locomotor deficits in (G4C2)29-expressing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Drosophila[1]
Dosage: 100 μM
Administration: fed
Result: Rescued G4C2 EHR-Related Pathologies in Drosophila.
分子量

636.51

Formula

C31H24O15
结构分类
初始来源

Streptomyces chrestomyceticus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chrexanthomycin C 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrexanthomycin CDNA/RNA SynthesisG-quadruplex (G4)C9orf72 GGGGCC (G4C2)expanded hexanucleotide repeat (EHR)amyotrophic lateral sclerosis (ALS)frontotemporal dementia (FTD)neurodegenerative diseaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Chrexanthomycin C
目录号：
HY-N10579
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z