2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Cicaprost

Cicaprost  (Synonyms: ZK 96480)

目录号: HY-19583
产品使用指南

摩尔计算器

Cicaprost (ZK 96480) 是一种前列环素受体 (IP) 激动剂。Cicaprost可引起动脉的浓度依赖性舒张，EC50 为 5.8 nM 。

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Cicaprost Chemical Structure

Cicaprost Chemical Structure

CAS No. : 94079-80-8

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Cicaprost 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cicaprost (ZK 96480) is a prostacyclin receptor (IP) agonist. Cicaprost causes a concentration-dependent relaxation of the artery with an EC50 of 5.8 nM [1]。

体外研究
(In Vitro)

Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM[2].
Cicaprost stimulates [3H]cyclic AMP production with EC50 values of 1.5-22 nM, and stimulates [3H]inositol phosphate production (EC50 values 49-457 nM) in all but the SK-N-SH cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cicaprost 相关抗体:

Cell Proliferation Assay[2]

Cell Line: HPASMC
Concentration: 10 pM, 100 pM, 1 nM, 10 nM, 100 nM, 1 μM, and 10 μM
Incubation Time:
Result: Dose-dependently inhibited proliferation with an EC50 of 24.1 nM.
体内研究
(In Vivo)

Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type (+/+) and IP−/− mice[4]
Dosage: 1 μg/kg
Administration: Intravenous injection
Result: Caused hypotension of ∼30 mm Hg in anaesthetized wild-type mice, whereas there was no change in blood pressure in IP-deficient mice even at 10 μg/kg.
分子量

374.47

Formula

C22H30O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cicaprost 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cicaprost94079-80-8ZK 96480ZK96480ZK-96480Prostaglandin Receptorprostacyclin receptorarteryhuman pulmonary artery smooth muscle cellsHPASMCInhibitorinhibitorinhibit

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