1. 天然产物
  2. 疾病研究领域 植物 萜类
  3. 毛茛科 炎症/免疫 三萜
  4. 升麻
  5. Cimicifugoside

Cimicifugoside 是一种从升麻单胞菌 Cimicifuga simplex 中提取的三萜类化合物,是一种新型特异性核苷转运 (nucleoside transport) 抑制剂,协同增强甲氨蝶呤细胞毒性作用。Cimicifugoside 具有免疫抑制活性,其优先针对 B 细胞功能,需要较大剂量来抑制 T 细胞功能。

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Cimicifugoside Chemical Structure

Cimicifugoside Chemical Structure

CAS No. : 66176-93-0

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1 mg ¥2082
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5 mg
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25 mg
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  • 生物活性

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生物活性

Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2].

IC50 & Target

Nucleoside transport[1]

分子量

674.82

Formula

C37H54O11

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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