1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Cryptophycin 1

Cryptophycin 1 (Synonyms: Cryptophycin A)

目录号: HY-136294
产品使用指南

Cryptophycin 1 是一种从 Nostoc sp. 中分离出来的有效的细胞毒性抗微管剂。Cryptophycin 1 可以诱导细胞凋亡,并具有抗肿瘤活性和出色的抗增殖能力。

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Cryptophycin 1 Chemical Structure

Cryptophycin 1 Chemical Structure

CAS No. : 124689-65-2

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Description

Cryptophycin 1 is a potent cytotoxic antimicrotubule agent which is isolated from Nostoc sp. Cryptophycin 1 can induce cells apoptosis, and exhibits antitumor activity and exceptional antiproliferative potency[1][2][3].

In Vitro

Cryptophycin 1 (50 pM) rapidly causes morphological changes consistent with the induction of apoptosis in SKOV3 and MDA-MB-435 cells[1].
Cryptophycin 1 (50 pM; 12-24 h) causes an accumulation of MDA-MB-435 cells in G2/M[1].
Cryptophycin 1 (100 nM; 1-7 min) markedly reduces the rates and extents of microtubule shortening and growing events and dramatically increases the duration of phases of attenuation or pause[2].

Apoptosis Analysis[1]

Cell Line: SKOV3 cells
Concentration: 50 pM
Incubation Time: 4 hours
Result: Caused rapid cell shrinkage, loss of the normal elliptical spheroid shape and the formation of membrane blebs.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-435 cells
Concentration: 50 pM
Incubation Time: 12, 18, 24 hours
Result: A doubling in the number of cells in G2/M at 12 hr.
Still a large number of cells (58%) in G2/M at 18 hr.
In Vivo

Cryptophycin 1 (i.v.) exhibits anti-tumor activity in mice[3].

Molecular Weight

655.18

Formula

C₃₅H₄₃ClN₂O₈

CAS No.

124689-65-2

SMILES

C[C@@H]([C@@](C/C=C/C(N[C@@H]1CC(C=C2)=CC(Cl)=C2OC)=O)([H])OC([C@@H](OC([C@@H](CNC1=O)C)=O)CC(C)C)=O)[C@]3([H])[C@](C4=CC=CC=C4)([H])O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cryptophycin 1Cryptophycin ACryptophycin1Cryptophycin-1Microtubule/TubulinApoptosiscytotoxicantimicrotubuleapoptosisantitumorantiproliferativeInhibitorinhibitorinhibit

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产品名称:
Cryptophycin 1
目录号:
HY-136294
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