2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Desirudin

Desirudin  (Synonyms: CGP 39393; Revasc)

目录号: HY-109549
产品使用指南

摩尔计算器

Desirudin (CGP 39393) 是一种凝血酶 (thrombin) 抑制剂。Desirudin 可抑制血栓形成和静脉淤血性血栓形成，可用于血小板减少症或血小板功能障碍相关的研究。

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Desirudin Chemical Structure

Desirudin Chemical Structure

CAS No. : 120993-53-5

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Desirudin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Desirudin (CGP 39393) is a thrombin inhibitor. Desirudin can inhibit the formation of blood clots and venous stasis thrombosis, which is used for the research of thrombocytopenia or platelet dysfunction[1][2].

IC50 & Target

ED50: 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].
体内研究
(In Vivo)

Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation[1].
Desirudin (0.01-1 mg/kg, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mongrel dogs model of cardiopulmonary bypass[1]
Dosage: 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h.
Administration: Administered as a bolus plus infusion
Result: Inhibited clot formation with no adverse hemodynamic or hematologic effects.
Animal Model: Rat shunt model of thrombus formation on a cotton-thread[2]
Dosage: 0.01-1 mg/kg approximately
Administration: Intravenous injections, subcutaneous injection
Result: Inhibited thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.).
Inhibited venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.).
Clinical Trial
CAS 号
中文名称

地西卢定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Desirudin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desirudin120993-53-5CGP 39393 Revasc地西卢定CGP39393CGP-39393ThrombinRecombinant hirudinantithromboticclot formationheparin-induced thrombocytopeniaInhibitorinhibitorinhibit

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