2. Immunology/Inflammation Apoptosis
  3. NO Synthase TNF Receptor
  4. DHU-Se1

DHU-Se1 是一种有效的抗炎剂。DHU-Se1 可以刺激巨噬细胞释放活性硒化合物，降低细胞炎症因子 (如 iNOS 和 TNF-α) 的表达。DHU-Se1 通过阻断巨噬细胞从 M0 到 M1 的极化来缓解炎症过程。

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DHU-Se1 Chemical Structure

DHU-Se1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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DHU-Se1 相关抗体

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Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1[1].

IC50 & Target

Selenium, iNOS, TNF-α[1]
体外研究
(In Vitro)

DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells[1].
DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors[1].
DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DHU-Se1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RAW cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Displayed low biological toxicity with a survival rate larger than 80%.

RT-PCR[1]

Cell Line: RAW cells (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the expression of TNF-α and iNOS significantly.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked.
Released the reactive selenium compound.
分子量

468.47

Formula

C23H23N3OSSe
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DHU-Se1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DHU-Se1NO SynthaseTNF ReceptorNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRAnti-inflammatoryRAW 264.7 macrophagesseleniumcellular inflammatory factorscell polarizationInhibitorinhibitorinhibit

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