2. Anti-infection Apoptosis
  3. Antibiotic Apoptosis
  4. Distamycin A

Distamycin A  (Synonyms: NSC-82150)

目录号: HY-112058
产品使用指南

摩尔计算器

Distamycin A (NSC-82150)，一种寡肽抗生素，是一种小沟结合剂，可结合 B 型 DNA，优先在富含 A/T 的位点。Distamycin A 可以改变烯二炔诱导的 DNA 切割位点并增强细胞凋亡。

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Distamycin A Chemical Structure

Distamycin A Chemical Structure

CAS No. : 636-47-5

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Distamycin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis[1][2][3].

体外研究
(In Vitro)

Distamycin A 与 DNA 结合，通过伸直螺旋轴并将其延长近 12-15% 来加宽小沟[2]。
Distamycin A 增强 5'-CCT-3'/3'-GGA-5' 和 5'-CCA-3'/3'-GGT-5' 序列的双链 DNA 切割[3]< /sup>.
Distamycin A 在 HL-60 细胞中增强 C1027 诱导的 DNA 阶梯形成和细胞毒性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Distamycin A 相关抗体:
分子量

481.51

Formula

C22H27N9O4
CAS 号
结构分类
初始来源

Streptomyces
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Distamycin A 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Distamycin A636-47-5NSC-82150NSC82150NSC 82150AntibioticApoptosisoligopeptideminor groove binderB-form DNAA/T rich sitesapoptosisInhibitorinhibitorinhibit

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