2. Anti-infection
  3. RSV
  4. Felvizumab

Felvizumab  (Synonyms: SB 209763; RSHZ19)

目录号: HY-P99615

摩尔计算器

Felvizumab (SB 209763) 是一种人源化 IgG1κ 单克隆抗体，靶向 RSV F 糖蛋白上的不同中和表位。

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Felvizumab Chemical Structure

Felvizumab Chemical Structure

CAS No. : 167747-20-8

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Felvizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV[1][2].

IC50 & Target

EC50: 0.49 μg/mL (RSV Type A in microneutralization assay), 0.95 μg/mL (RSV Type A in fusion inhibition assay)[2]
体外研究
(In Vitro)

Felvizumab (RSHZ19) (2 h or 4 h) 抑制 RSV A 型，微量中和试验中 EC50 为 0.49 ± 0.37 μg/mL，融合抑制试验中 EC50 为 0.95 ± 0.13 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Felvizumab 相关抗体:
体内研究
(In Vivo)

Felvizumab (RSHZ19) (0.625-5.0 mg/kg; intramuscular injection; once) 在 RSV 感染大鼠模型中对 A 和 B 亚型 RSV 有效[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cotton rats, RSV infection model[2]
Dosage: 0.625, 1.25, 2.5, and 5.0 mg/kg
Administration: Intramuscular injection, 1 day before infection
Result: Significantly reduced lung RSV titer.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Felvizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Felvizumab167747-20-8SB 209763 RSHZ19SB209763SB-209763RSHZ19RSHZ 19RSHZ-19RSVRespiratory syncytial virusF glycoproteinCotton ratsmicroneutralization assayfusion inhibition assayInhibitorinhibitorinhibit

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