2. Apoptosis
  3. Ferroptosis
  4. Ferroptosis-IN-8

Ferroptosis-IN-8 (化合物 B4) 是一种铁死亡抑制剂，IC50 值为 40.49 nM。Ferroptosis-IN-8 通过其固有的抗氧化能力来抑制 RSL3 (HY-100218A) 或 FIN56 (HY-103087) 诱导的铁死亡，显著减轻肝肾损伤，有望用于预防铁死亡相关疾病。

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Ferroptosis-IN-8

Ferroptosis-IN-8 Chemical Structure

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规格 价格 是否有货 数量
5 mg ￥720
In-stock
10 mg ￥1143
In-stock
25 mg ￥2286
In-stock
50 mg ￥3654
In-stock
100 mg ￥5850
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Ferroptosis-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis[1].

IC50 & Target

IC50: 40.49 nM (Ferroptosis)
体外研究
(In Vitro)

Ferroptosis-IN-8 (化合物 B4) (200 nM) 有效将 HKC, HK-2, Khos, SW480 和 HTR-8/SVneo 细胞从 RSL3 或 FIN56 诱导的脱铁蛋白中拯救出来[1]。
Ferroptosis-IN-8 (化合物 B4) (200 nM) 主要依赖其固有的抗氧化能力而非包括脂质氧化代谢在内的经典信号通路来对抗铁死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells treatment with RSL3 or FIN56
Concentration: 200 nM
Incubation Time: 24 h
Result: Effectively rescued HKC, HK-2, HT-1080, Khos, SW480, and HTR-8/SVneo cells from ferroptosis induced by RSL3 or FIN56.

Real Time qPCR[1]

Cell Line: HT-1080 cell
Concentration: 200 nM
Incubation Time:
Result: Didn't significantly affect the protein levels of key factors related to lipid metabolism (ACSL4, ALOX15, and COX2), glutathione metabolism pathways (GPX4, SLC7A11), and iron metabolism (DMT1, TFRC, and FTH1)
体内研究
(In Vivo)

Ferroptosis-IN-8 (化合物 B4) (10 mg/kg, 两次, 缺血开始前1 h, 腹腔注射) 减轻肾缺血再灌注损伤小鼠模型中的组织损伤[1]。
Ferroptosis-IN-8 (化合物 B4) (10 mg/kg, 腹腔注射) 通过抑制脱铁蛋白减轻对乙酰氨基酚诱导的小鼠急性肝损伤模型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: acetaminophen-induced acute liver injury mice model[1].
Dosage: 10 mg/kg
Administration: intraperitoneal injection (i.p.)
Result: Attenuated the increased plasma ALT and AST levels induced by acetaminophen, effectively reduced the injury response induced by acetaminophen[1].
Animal Model: kidney ischemia−reperfusion injury mice model[1].
Dosage: 10 mg/kg, twice, 1 h before ischemia onset.
Administration: intraperitoneal injection (i.p.)
Result: Reduced the levels of creatinine and BUN and alleviated the increase in KIM-1 levels in the I/R model[1].
Animal Model:
Dosage:
Administration:
Result:
Animal Model:
Dosage:
Administration:
Result:
分子量

285.30

Formula

C15H15N3O3
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (175.25 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5051 mL 17.5254 mL 35.0508 mL
5 mM 0.7010 mL 3.5051 mL 7.0102 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ferroptosis-IN-8 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5051 mL 17.5254 mL 35.0508 mL 87.6271 mL
5 mM 0.7010 mL 3.5051 mL 7.0102 mL 17.5254 mL
10 mM 0.3505 mL 1.7525 mL 3.5051 mL 8.7627 mL
15 mM 0.2337 mL 1.1684 mL 2.3367 mL 5.8418 mL
20 mM 0.1753 mL 0.8763 mL 1.7525 mL 4.3814 mL
25 mM 0.1402 mL 0.7010 mL 1.4020 mL 3.5051 mL
30 mM 0.1168 mL 0.5842 mL 1.1684 mL 2.9209 mL
40 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1907 mL
50 mM 0.0701 mL 0.3505 mL 0.7010 mL 1.7525 mL
60 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4605 mL
80 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
100 mM 0.0351 mL 0.1753 mL 0.3505 mL 0.8763 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-8FerroptosisFerroptosis inhibitorsRSL3lipid ROS levelskidney (I/R) injuryacute liver injuryInhibitorinhibitorinhibit

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目录号：
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