1. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  2. NADPH Oxidase Reactive Oxygen Species
  3. Fulvene-5

Fulvene-5 是一种有效的 NADPH 氧化酶 4 (NOX4) 抑制剂,具有抗氧化特性。Fulvene-5 是一种活性氧 (ROS) 修饰剂和有效的辐射防护剂,并具有抗肿瘤活性。

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Fulvene-5 Chemical Structure

Fulvene-5 Chemical Structure

CAS No. : 1075723-01-1

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity[1][2][3].

IC50 & Target

NOX4

 

体外研究
(In Vitro)

Fulvene-5 (10 µM; 1 hour) facilitates the reversal of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures adaptive responses from pro-survival to radio-sensitization and vice versa. These changes are accompanied by corresponding reversals in the translocation of survivin to the nuclei of TP53 WT and to the cytoplasm of TP53 Mut cells. The potential role of NOX4 in the expression of the survivin-associated adaptive response is investigated by transfecting HCT116 cells with NOX4 siRNA oligomers to inhibit NOX4 expression. Under these conditions NOX4 expression is inhibited by about 50%[1].
Fulvene-5 (0.5-1.0 μM) treatment decreases the expression of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in a dose-dependent manner in bEnd.3 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Fulvene-5 (120 mg/kg/d; intraperitoneal injection; daily; for 2 weeks; nude mice) treatment potently inhibits hemangioma growth in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice injected with bEnd.3 cells[2]
Dosage: 120 mg/kg/d
Administration: Intraperitoneal injection; daily; for 2 weeks
Result: Tumor growth in mice was significantly reduced.
分子量

358.43

Formula

C26H18N2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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