CDH7 - cadherin 7 Gene

中文名称：钙粘蛋白 7

种属: Homo sapiens

同用名: CDH7L1

关于 CDH7

功能概要

该基因编码钙粘蛋白超家族的 II 型经典钙粘蛋白。可变剪接导致多个转录本变体，其中至少一个编码前原蛋白，该前原蛋白经过蛋白水解处理以产生成熟的糖蛋白。这种钙依赖性细胞粘附分子由五个细胞外钙粘蛋白重复序列、一个跨膜区域和一个高度保守的细胞质尾部组成。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的组氨酸-丙氨酸-缬氨酸 (HAV) 细胞粘附识别序列来定义的。钙粘蛋白以嗜同性方式介导细胞-细胞结合，有助于异质细胞类型的分类。该基因的突变可能与人类患者的双相情感障碍有关。该基因存在于 18 号染色体上的基因簇中。[RefSeq 提供，2016 年 5 月]

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) Cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I Cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]