2. Gene
  3. TRIM10 - tripartite motif containing 10 Gene

TRIM10 - tripartite motif containing 10 Gene

  • 基因
  • 蛋白
  • 直系同源

中文名称：含三方基序 10

种属: Homo sapiens

同用名: RNF9; HERF1; RFB30

基因 ID: 10107 | 基因类型: protein coding

关于 TRIM10

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,151,943-30,164,009 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 96 orthologues and 80 paralogues. Biased expression in bone marrow (RPKM 6.5), kidney (RPKM 1.8) and 6 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白质定位于细胞质体。对小鼠的研究表明，这种蛋白质在红细胞的终末分化中发挥作用。该基因的交替剪接产生两种编码不同亚型的转录本变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

TRIM10 基因产物(2)

mRNA Protein Name
NM_006778.4 NP_006769.2 tripartite motif-containing protein 10 isoform 1
NM_052828.3 NP_439893.2 tripartite motif-containing protein 10 isoform 2

TRIM10 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 60)

zf-B_box

zf-B_box: B-box zinc finger (95 - 132)

PRY

PRY: SPRY-associated domain (313 - 359)

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  • 395 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 10

B30-RING finger protein

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRIM10 MGD MGI:1338757
Canis familiaris TRIM10 VGNC VGNC:49639
Rattus norvegicus TRIM10 RGD RGD:1359438
Bos taurus TRIM10 VGNC VGNC:36312
Macaca mulatta TRIM10 VGNC VGNC:78550