2. Gene
  3. PREB - prolactin regulatory element binding Gene

PREB - prolactin regulatory element binding Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：催乳素调节元件结合

种属: Homo sapiens

同用名: SEC12

基因 ID: 10113 | 基因类型: protein coding

关于 PREB

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,130,756-27,134,636 (from NCBI)

This gene has 9 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in ovary (RPKM 22.2), fat (RPKM 20.3) and 25 other tissues.

功能概要

该基因编码的蛋白质特异性结合催乳素 (PRL) 启动子的 Pit1 结合元件。这种蛋白质可能充当转录调节因子，并被认为与在部分 2p 三体综合征患者中观察到的一些发育异常有关。该基因与相对链上含有 1 (ABHD1) 基因的脱氢酶结构域重叠。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that specifically binds to a Pit1-binding element of the Prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

PREB 基因产物(5)

mRNA Protein Name
NM_001330484.2 NP_001317413.1 prolactin regulatory element-binding protein isoform 2
NM_001330485.2 NP_001317414.1 prolactin regulatory element-binding protein isoform 3
NM_001330486.2 NP_001317415.1 prolactin regulatory element-binding protein isoform 4
NM_001330487.2 NP_001317416.1 prolactin regulatory element-binding protein isoform 5
NM_013388.6 NP_037520.1 prolactin regulatory element-binding protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
32358066 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25202031 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: 通过直接分析推断
32358066 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
25202031 GOA
involved in regulation of COPII vesicle coating IDA
IDA: 通过直接分析推断
32358066 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
25202031 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10194769 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PREB 蛋白结构

WD40

WD40: WD domain, G-beta repeat (160 - 182)

WD40

WD40: WD domain, G-beta repeat (188 - 222)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

prolactin regulatory element-binding protein

mammalian guanine nucleotide exchange factor mSec12

PREB 抗体

目录号 产品名 应用 反应物种
HY-P81984 PREB Antibody (YA1729) WB, IHC-P, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116170 SN34037 / 否
HY-E70016 Terminal deoxyribonucleotidyltransferase / 否
HY-RS11080 PREB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PREB MGD MGI:1355326
Bos taurus PREB VGNC VGNC:33305
Felis catus PREB VGNC VGNC:69039
Canis familiaris PREB VGNC VGNC:44954
Macaca mulatta PREB VGNC VGNC:103847
Rattus norvegicus PREB RGD RGD:61929
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