RASA4 - RAS p21 protein activator 4 Gene

中文名称：RAS p21 蛋白激活因子 4

种属: Homo sapiens

同用名: GAPL; CAPRI

关于 RASA4

功能概要

该基因编码 GTPase 激活蛋白 GAP1 家族的成员，该蛋白抑制 Ras/丝裂原活化蛋白激酶通路以响应 Ca (2+) 。增加细胞内 Ca (2+) 水平的刺激会导致该蛋白质易位至质膜，并在此处激活 Ras GTPase 活性。因此，Ras 从活性 GTP 结合状态转变为非活性 GDP 结合状态，不再激活调节基因表达、细胞生长和分化的下游通路。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]