1. Gene
  2. OLFM1 - olfactomedin 1 Gene

OLFM1 - olfactomedin 1 Gene

中文名称:嗅觉调节素 1

种属: Homo sapiens

同用名: AMY; NOE1; OlfA; NOELIN1

基因 ID: 10439 | 基因类型: protein coding

关于 OLFM1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,075,505-135,121,184 (from NCBI)

This gene has 12 transcripts (splice variants), 270 orthologues and 9 paralogues. Biased expression in brain (RPKM 118.4), adrenal (RPKM 7.6) and 1 other tissue.

功能概要

该基因产物与大鼠神经元嗅觉调节素相关 ER 定位蛋白具有广泛的序列相似性。虽然编码蛋白的确切功能尚不清楚,但其在大脑中的大量表达表明它可能在神经组织中发挥重要作用。已经为该基因发现了几种编码不同亚型的可变剪接转录物。[RefSeq 提供,2008 年 7 月]

This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OLFM1 基因产物(4)

mRNA Protein Name
NM_001282611.2 NP_001269540.1 noelin isoform 4 precursor
NM_001282612.1 NP_001269541.1 noelin isoform 5
NM_006334.4 NP_006325.1 noelin isoform 2 precursor
NM_014279.5 NP_055094.1 noelin isoform 1 precursor

OLFM1 蛋白结构

Noelin-1

Noelin-1: Neurogenesis glycoprotein (54 - 152)

OLF

OLF: Olfactomedin-like domain (230 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

noelin

neuroblastoma protein

关联疾病

疾病名称 别名
Sarcosinemia

Sarcosine Dehydrogenase Complex Deficiency

Sard Deficiency

Sardh Deficiency

SARCOS

Hypersarcosinemia

Sardhd

Demethylation Defect Of N-Methylglycine

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OLFM1 VGNC VGNC:75416
Felis catus OLFM1 VGNC VGNC:63958
Rattus norvegicus OLFM1 RGD RGD:620320
Canis familiaris OLFM1 VGNC VGNC:55713
Bos taurus OLFM1 VGNC VGNC:32417
Mus musculus OLFM1 MGD MGI:1860437