TCFL5 - transcription factor like 5 Gene

中文名称：转录因子样 5

种属: Homo sapiens

同用名: CHA; Figlb; SOSF1; E2BP-1; bHLHe82

基因 ID: 10732 | 基因类型: protein coding

关于 TCFL5

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,841,005-62,861,822 (from NCBI)

This gene has 2 transcripts (splice variants) and 173 orthologues. Broad expression in testis (RPKM 22.8), thyroid (RPKM 7.1) and 19 other tissues.

功能概要

启用 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调控区域序列特异性 DNA 结合活性。参与多个过程，包括 RNA 聚合酶 II 对转录的负调控；调节细胞群增殖；和精子发生。位于核内。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TCFL5 基因产物(2)

mRNA	Protein	Name
NM_001301726.2	NP_001288655.1	transcription factor-like 5 protein isoform 2
NM_006602.4	NP_006593.2	transcription factor-like 5 protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	9763657	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12923186	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12923186	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12923186	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9763657	GOA
involved in regulation of cell differentiation	IEP IEP: 通过表达模式推断	9763657	GOA
involved in regulation of cell population proliferation	IEP IEP: 通过表达模式推断	9763657	GOA
involved in spermatogenesis	IEP IEP: 通过表达模式推断	9763657	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	9763657	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCFL5 蛋白结构

HLH

0
100
200
300
400
500 a.a.

蛋白主名

其他名称

transcription factor-like 5 protein

HPV-16 E2-binding protein 1

关联疾病

疾病名称

别名

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Bile Duct Cancer

Bile Duct Carcinoma	Extrahepatic Bile Duct Carcinoma
Carcinoma Of Extrahepatic Bile Duct	Extrahepatic Bile Duct Cancer
Bile Duct Neoplasms	Bile Duct Tumor
Ca Extrahepatic Bile Ducts	Malignant Neoplasm Of The Extrahepatic Bile Duct
Bile Duct Extrahepatic Carcinoma	Malignant Tumor Of Extrahepatic Bile Duct

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Mixed Germ Cell-Sex Cord Neoplasm

Mixed Germ Cell-Sex Cord-Stromal Tumor

Mixed Germ Cell-Sex Cord Tumor

Trypanosomiasis

Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Bile Duct Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14311	TCFL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21781	Tcfl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28298	Tcfl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TCFL5	MGD	MGI:2672878
Macaca mulatta	TCFL5	VGNC	VGNC:98458
Felis catus	TCFL5	VGNC	VGNC:81236
Rattus norvegicus	TCFL5	RGD	RGD:1305899
Canis familiaris	TCFL5	VGNC	VGNC:49660

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TCFL5 - transcription factor like 5 Gene

关于 TCFL5

功能概要

TCFL5 基因产物(2)

TCFL5 蛋白结构

关联疾病

直系同源

热门区域

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TCFL5 - transcription factor like 5 Gene

关于 TCFL5

功能概要

TCFL5 基因产物(2)

TCFL5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z