1. Gene
  2. MRPL3 - mitochondrial ribosomal protein L3 Gene

MRPL3 - mitochondrial ribosomal protein L3 Gene

中文名称:线粒体核糖体蛋白 L3

种属: Homo sapiens

同用名: MRL3; RPML3; COXPD9

基因 ID: 11222 | 基因类型: protein coding

关于 MRPL3

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:131,462,212-131,502,971 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 34.3), colon (RPKM 33.4) and 25 other tissues.

功能概要

哺乳动物线粒体核糖体蛋白由核基因编码,有助于线粒体内的蛋白质合成。线粒体核糖体 (线粒体核糖体) 由一个小的 28S 亚基和一个大的 39S 亚基组成。与原核核糖体相比,它们估计有 75% 的蛋白质与 rRNA 组成,而原核核糖体的比例是相反的。哺乳动物 线粒体核糖体 和原核核糖体之间的另一个区别是后者包含 5S rRNA。在不同的物种中,构成核糖体的蛋白质在序列上有很大差异,有时在生化特性上也有很大差异,这使得序列同源性难以识别。该基因编码属于 L3P 核糖体蛋白家族的 39S 亚基蛋白。在染色体 13q 上发现了与该基因对应的假基因。[RefSeq 提供,2008 年 7 月]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

MRPL3 基因产物(1)

mRNA Protein Name
NM_007208.4 NP_009139.1 39S ribosomal protein L3, mitochondrial

MRPL3 蛋白结构

Ribosomal_L3

Ribosomal_L3: Ribosomal protein L3 (103 - 300)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
蛋白主名 其他名称

39S ribosomal protein L3, mitochondrial

L3mt

关联疾病

疾病名称 别名
Combined Oxidative Phosphorylation Deficiency 9

COXPD9

Combined Oxidative Phosphorylation Defect Type 9

Combined Oxidative Phosphorylation Deficiency, Type 9

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder

Tic Disorders

Tic Disorder

Tic Disorder Nos

Tic Nos

Tic Spasm Nos

Marshall-Smith Syndrome

MRSHSS

Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome

Mss

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MRPL3 VGNC VGNC:74725
Mus musculus MRPL3 MGD MGI:2137204
Rattus norvegicus MRPL3 RGD RGD:1306391
Canis familiaris MRPL3 VGNC VGNC:43390
Bos taurus MRPL3 VGNC VGNC:31630
Felis catus MRPL3 VGNC VGNC:63601