2. Gene
  3. ROMO1 - reactive oxygen species modulator 1 Gene

ROMO1 - reactive oxygen species modulator 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：活性氧调节因子 1

种属: Homo sapiens

同用名: MTGM; MTGMP; C20orf52; bA353C18.2

基因 ID: 140823 | 基因类型: protein coding

关于 ROMO1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,699,405-35,700,980 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种线粒体膜蛋白，负责增加细胞中活性氧 (ROS) 的水平。该蛋白还通过诱导细菌膜破裂而对多种细菌具有抗菌活性。[RefSeq 提供，2014 年 11 月]

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of Reactive Oxygen Species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing Bacterial membrane breakage. [provided by RefSeq, Nov 2014]

ROMO1 基因产物(1)

mRNA Protein Name
NM_080748.3 NP_542786.1 reactive oxygen species modulator 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoatomic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
29545371 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: 通过突变表型推断
22083756 GOA
involved in cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
18836179 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: 通过直接分析推断
22083756 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
22083756 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
22083756 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
22083756 GOA
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
22083756 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
22083756 GOA
involved in killing of cells of another organism IMP
IMP: 通过突变表型推断
22083756 GOA
involved in monoatomic cation transmembrane transport IDA
IDA: 通过直接分析推断
29545371 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
18313394 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
16842742 GOA
involved in protein insertion into mitochondrial inner membrane IMP
IMP: 通过突变表型推断
30598479 GOA
involved in replicative senescence IMP
IMP: 通过突变表型推断
18836179 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TIM23 mitochondrial import inner membrane translocase complex IDA
IDA: 通过直接分析推断
30598479 GOA
is active in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
29545371 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
16842742 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ROMO1 蛋白结构

Romo1

Romo1: Reactive mitochondrial oxygen species modulator 1 (13 - 79)

  • 0
  • 79 a.a.
蛋白主名 其他名称

reactive oxygen species modulator 1

PCM19

ROMO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
种属内
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
种属内
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
种属内
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属内
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Premature Ovarian Failure 19

POF19

Primary Ovarian Insufficiency 19

Poi19

Ovarian Failure, Premature, Type 19
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12122 ROMO1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20097 Romo1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26600 Romo1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ROMO1 VGNC VGNC:108028
Mus musculus ROMO1 MGD MGI:1914317
Felis catus ROMO1 VGNC VGNC:81211
Rattus norvegicus ROMO1 RGD RGD:1587111
Canis familiaris ROMO1 VGNC VGNC:45691
Bos taurus ROMO1 VGNC VGNC:34085
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