2. Gene
  3. SPPL2C - signal peptide peptidase like 2C Gene

SPPL2C - signal peptide peptidase like 2C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号肽肽酶样 2C

种属: Homo sapiens

同用名: IMP5

基因 ID: 162540 | 基因类型: protein coding

关于 SPPL2C

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,844,881-45,847,067 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 71 orthologues and 4 paralogues.

功能概要

启用蛋白质同源二聚化活性。预计参与膜蛋白的蛋白水解。位于内质网膜上。是内质网膜胞质侧的组成部分和内质网膜腔侧的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein homodimerization activity. Predicted to be involved in membrane protein proteolysis. Located in endoplasmic reticulum membrane. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPPL2C 基因产物(1)

mRNA Protein Name
NM_175882.3 NP_787078.2 signal peptide peptidase-like 2C precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15385547 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
17965014 GOA
NOT involved in membrane protein intracellular domain proteolysis IMP
IMP: 通过突变表型推断
16829952 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic side of endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
15385547 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
16829952 GOA
located in lumenal side of endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
15385547 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPPL2C 蛋白结构

PA

PA: PA domain (83 - 163)

Peptidase_A22B

Peptidase_A22B: Signal peptide peptidase (250 - 527)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
蛋白主名 其他名称

signal peptide peptidase-like 2C

IMP-5

SPPL2C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SPPL2C Q8IUH8 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
SPPL2C Q8IUH8 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
SPPL2C Q8IUH8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
SPPL2C Q8IUH8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 17q21.31 Duplication Syndrome

17q21.31 Microduplication Syndrome

Trisomy 17q21.31

Dup(17)(Q21.31)
Koolen-De Vries Syndrome

KDVS

17q21.31 Microdeletion Syndrome

Microdeletion 17q21.31 Syndrome

Chromosome 17q21.31 Deletion Syndrome

Koolen De Vries Syndrome

Kansl1-Related Intellectual Disability Syndrome

Chromosome 17q21.31 Microdeletion Syndrome

Monosomy 17q21.31

17q21.31 Deletion Syndrome

Koolen Syndrome

Del(17)(Q21.31)
Caplan'S Syndrome

Caplan Syndrome

Caplan'S Disease

Caplans Syndrome

Rheumatoid Pneumoconiosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13706 SPPL2C Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SPPL2C VGNC VGNC:46760
Bos taurus SPPL2C VGNC VGNC:35236
Macaca mulatta SPPL2C VGNC VGNC:104659
Mus musculus SPPL2C MGD MGI:3045264
Felis catus SPPL2C VGNC VGNC:97643
Rattus norvegicus SPPL2C RGD RGD:1560562
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z