Kcnq1 - potassium voltage-gated channel, subfamily Q, member 1 Gene

种属: Mus musculus

同用名: Kcna9; KVLQT1

基因 ID: 16535 | 基因类型: protein coding

关于 Kcnq1

功能概要

Enables voltage-gated Potassium Channel activity. Involved in several processes, including animal organ development; inorganic ion homeostasis; and regulation of heart contraction. Acts upstream of or within circulatory system development; negative regulation of gene expression; and regulation of gene expression by genetic imprinting. Located in apical part of cell; neuron projection; and transport vesicle. Part of voltage-gated Potassium Channel complex. Is active in several cellular components, including apical plasma membrane; basolateral part of cell; and ciliary base. Is expressed in several structures, including alimentary system; extraembryonic component; heart; hemolymphoid system gland; and reproductive system. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome 1. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq1 基因产物(3)

mRNA	Protein	Name
NM_001412611.1	NP_001399540.1	potassium voltage-gated channel subfamily KQT member 1 isoform 2
NM_001412612.1	NP_001399541.1	potassium voltage-gated channel subfamily KQT member 1 isoform 3
NM_008434.3	NP_032460.2	potassium voltage-gated channel subfamily KQT member 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24595108	MGI
enables voltage-gated potassium channel activity	IDA IDA: 通过直接分析推断	8900282	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adrenergic receptor signaling pathway	IMP IMP: 通过突变表型推断	17597584	MGI
involved in auditory receptor cell development	IMP IMP: 通过突变表型推断	26084842	MGI
involved in cardiac conduction	IMP IMP: 通过突变表型推断	23542581	MGI
involved in cardiac muscle contraction	IMP IMP: 通过突变表型推断	17660684	MGI
involved in cellular response to epinephrine stimulus	IMP IMP: 通过突变表型推断	17597584	MGI
involved in chloride ion homeostasis	IMP IMP: 通过突变表型推断	16314573	MGI
involved in cochlea development	IMP IMP: 通过突变表型推断	15891643	MGI
involved in corticosterone secretion	IMP IMP: 通过突变表型推断	17660684	MGI
involved in detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: 通过突变表型推断	15891643	MGI
acts upstream of or within digestive system process	IMP IMP: 通过突变表型推断	23975432	MGI
involved in erythrocyte differentiation	IMP IMP: 通过突变表型推断	16314573	MGI
involved in gastric acid secretion	IMP IMP: 通过突变表型推断	15385447	MGI
involved in gastrin-induced gastric acid secretion	IMP IMP: 通过突变表型推断	17660684	MGI
involved in glucose metabolic process	IMP IMP: 通过突变表型推断	19369585	MGI
involved in heart development	IMP IMP: 通过突变表型推断	15498462	MGI
acts upstream of or within inner ear development	IMP IMP: 通过突变表型推断	15385447	MGI
involved in inner ear development	IMP IMP: 通过突变表型推断	11120752	MGI
involved in inner ear morphogenesis	IMP IMP: 通过突变表型推断	11226272	MGI
involved in intracellular chloride ion homeostasis	IDA IDA: 通过直接分析推断	11527966	MGI
involved in intracellular chloride ion homeostasis	IMP IMP: 通过突变表型推断	11527966	MGI
involved in iodide transport	IMP IMP: 通过突变表型推断	22549510	MGI
involved in membrane repolarization	IMP IMP: 通过突变表型推断	16314573	MGI
involved in membrane repolarization during action potential	IMP IMP: 通过突变表型推断	20368164	MGI
acts upstream of or within membrane repolarization during ventricular cardiac muscle cell action potential	IMP IMP: 通过突变表型推断	12766260	MGI
involved in non-motile cilium assembly	IDA IDA: 通过直接分析推断	26546361	MGI
involved in non-motile cilium assembly	IMP IMP: 通过突变表型推断	26546361	MGI
involved in potassium ion homeostasis	IMP IMP: 通过突变表型推断	16314573	MGI
involved in potassium ion import across plasma membrane	IMP IMP: 通过突变表型推断	19369585	MGI
involved in potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	11527966	MGI
involved in potassium ion transmembrane transport	IMP IMP: 通过突变表型推断	11527966	MGI
involved in regulation of blood pressure	IMP IMP: 通过突变表型推断	17660684	MGI
involved in regulation of gastric acid secretion	IMP IMP: 通过突变表型推断	16314573	MGI
involved in regulation of heart rate	IMP IMP: 通过突变表型推断	20368164	MGI
involved in regulation of transporter activity	IMP IMP: 通过突变表型推断	24595108	MGI
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: 通过突变表型推断	11226272	MGI
involved in regulation of voltage-gated sodium channel activity	IMP IMP: 通过突变表型推断	23542581	MGI
involved in renal absorption	IMP IMP: 通过突变表型推断	16314573	MGI
involved in renal sodium ion absorption	IMP IMP: 通过突变表型推断	16314573	MGI
involved in response to insulin	IMP IMP: 通过突变表型推断	19369585	MGI
involved in rhythmic behavior	IMP IMP: 通过突变表型推断	15891643	MGI
involved in sensory perception of sound	IMP IMP: 通过突变表型推断	11226272	MGI
involved in social behavior	IMP IMP: 通过突变表型推断	15498462	MGI
involved in sodium ion transport	IDA IDA: 通过直接分析推断	11527966	MGI
involved in sodium ion transport	IMP IMP: 通过突变表型推断	11527966	MGI
involved in stomach development	IMP IMP: 通过突变表型推断	15385447	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in apical part of cell	IDA IDA: 通过直接分析推断	16896189	MGI
is active in apical plasma membrane	IDA IDA: 通过直接分析推断	11223304	MGI
located in apical plasma membrane	IDA IDA: 通过直接分析推断	16901941	MGI
is active in basolateral part of cell	IDA IDA: 通过直接分析推断	11527966	MGI
is active in ciliary base	IDA IDA: 通过直接分析推断	26546361	MGI
is active in cytoplasm	IDA IDA: 通过直接分析推断	16896189	MGI
located in lumenal side of membrane	IDA IDA: 通过直接分析推断	16901941	MGI
is active in neuron projection	IMP IMP: 通过突变表型推断	20368164	MGI
is active in neuronal cell body	IMP IMP: 通过突变表型推断	20368164	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	16901941	MGI
part of potassium channel complex	IDA IDA: 通过直接分析推断	19218243	MGI
is active in transport vesicle	IDA IDA: 通过直接分析推断	23154976	MGI
part of voltage-gated potassium channel complex	IDA IDA: 通过直接分析推断	24595108	MGI
part of voltage-gated potassium channel complex	IPI IPI: 通过物理相互作用推断	8900282	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

potassium voltage-gated channel subfamily KQT member 1

IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1	KQT-like 1
voltage-gated potassium channel subunit Kv7.1

目录号	产品名	作用方式	纯度	是否罕见病
HY-12637	Hexachlorophene		99.66%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108577	XE991 dihydrochloride	Inhibitor	99.63%	否
HY-12343	ML277	Activator	98.46%	否
HY-17442	Azathramycin	Inhibitor	99.85%	否
HY-108591	L-364,373	Activator	99.67%	否
HY-108577A	XE991	Inhibitor	99.69%	否
HY-108587	ICA 110381	Modulator	99.85%	否
HY-18063	ML252	Inhibitor	99.65%	否
HY-145992	KCNQ1 activator-1	Activator	99.03%	否
HY-121520	Docosahexaenoyl glycine	Activator	/	否
HY-122504	Linoleoyl glycine	Inhibitor	/	否
HY-RS07173	KCNQ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-121977	IKs124	Inhibitor	/	否
HY-18063A	ML252 hydrochloride	Inhibitor	/	否
HY-RS18286	Kcnq1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24764	Kcnq1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Kcnq1	NCBI	NCBI:3784

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Kcnq1 - potassium voltage-gated channel, subfamily Q, member 1 Gene

关于 Kcnq1

功能概要

Kcnq1 基因产物(3)

直系同源

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Kcnq1 - potassium voltage-gated channel, subfamily Q, member 1 Gene

关于 Kcnq1

功能概要

Kcnq1 基因产物(3)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z