2. Gene
  3. Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pkr; Tik; Prkr; 2310047A08Rik; 4732414G15Rik

基因 ID: 19106 | 基因类型: protein coding

关于 Eif2ak2

功能概要

Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of intracellular signal transduction; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of apoptotic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak2 基因产物(1)

mRNA Protein Name
NM_011163.4 NP_035293.1 interferon-induced, double-stranded RNA-activated protein kinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21703541 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7519779 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
7519779 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
21123651 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
15542627 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
15542627 MGI
involved in negative regulation of viral genome replication IMP
IMP: 通过突变表型推断
20038207 MGI
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
20038207 MGI
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
20038207 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
20038207 MGI
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
20038207 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
7519779 MGI
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
22801494 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
7519779 MGI
involved in regulation of NLRP3 inflammasome complex assembly IMP
IMP: 通过突变表型推断
22801494 MGI
involved in regulation of hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
23403623 MGI
involved in regulation of hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
23403623 MGI
involved in regulation of hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
23403623 MGI
acts upstream of or within translation IDA
IDA: 通过直接分析推断
7519779 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interferon-induced, double-stranded RNA-activated protein kinase

IFN- type I-induced and dsRNA-activated kinase

IFN-induced and double-stranded RNA-activated kinase

P1/eIF-2A protein kinase

T-cell viral integration site

dsRNA-activated kinase

eIF-2 alpha

eIF-2A protein kinase 2

interferon-inducible RNA-dependent

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174720 Human EIF2AK2 mRNA / 否
HY-RS18207 Eif2ak2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24684 Eif2ak2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Eif2ak2 NCBI NCBI:5610
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