2. Gene
  3. NLGN1 - neuroligin 1 Gene

NLGN1 - neuroligin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经胶素 1

种属: Homo sapiens

同用名: NL1

基因 ID: 22871 | 基因类型: protein coding

关于 NLGN1

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:173,395,952-174,294,372 (from NCBI)

This gene has 11 transcripts (splice variants), 264 orthologues, 13 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 1.7), testis (RPKM 0.4) and 11 other tissues.

功能概要

该基因编码神经元细胞表面蛋白家族的一个成员。该家族的成员可作为 β-神经肽的剪接位点特异性配体，并可能参与中枢神经系统突触的形成和重塑。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN1 基因产物(15)

mRNA Protein Name
NM_001365923.2 NP_001352852.1 neuroligin-1 isoform 1
NM_001365924.2 NP_001352853.1 neuroligin-1 isoform 2
NM_001365925.2 NP_001352854.1 neuroligin-1 isoform 2
NM_001365926.2 NP_001352855.1 neuroligin-1 isoform 2
NM_001365927.2 NP_001352856.1 neuroligin-1 isoform 1
NM_001365928.2 NP_001352857.1 neuroligin-1 isoform 2
NM_001365929.2 NP_001352858.1 neuroligin-1 isoform 3
NM_001365930.2 NP_001352859.1 neuroligin-1 isoform 3
NM_001365931.2 NP_001352860.1 neuroligin-1 isoform 3
NM_001365932.2 NP_001352861.1 neuroligin-1 isoform 3
NM_001365933.2 NP_001352862.1 neuroligin-1 isoform 3
NM_001365934.2 NP_001352863.1 neuroligin-1 isoform 4
NM_001365935.2 NP_001352864.1 neuroligin-1 isoform 4
NM_001365936.2 NP_001352865.1 neuroligin-1 isoform 4
NM_014932.5 NP_055747.1 neuroligin-1 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IDA
IDA: 通过直接分析推断
17474715 GOA
enables scaffold protein binding IDA
IDA: 通过直接分析推断
17474715 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of dendritic spine morphogenesis IGI
IGI: 通过遗传相互作用推断
23143522 GOA
involved in nervous system development IMP
IMP: 通过突变表型推断
28841651 GOA
involved in neuron projection development IDA
IDA: 通过直接分析推断
22750515 GOA
involved in positive regulation of dendritic spine development IGI
IGI: 通过遗传相互作用推断
23143522 GOA
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
23143522 GOA
acts upstream of or within positive regulation of synapse assembly IDA
IDA: 通过直接分析推断
24613359 GOA
involved in regulation of NMDA receptor activity IGI
IGI: 通过遗传相互作用推断
23143522 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IMP
IMP: 通过突变表型推断
28841651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NLGN1 蛋白结构

COesterase

COesterase: Carboxylesterase family (32 - 606)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
蛋白主名 其他名称

neuroligin-1

重组 NLGN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74705 NLGN1 Protein, Human (HEK293, C-His) Q8N2Q7-2/NP_055747.1 (Q46-S677) ≥95%

关联疾病

疾病名称 别名
Autism 20

Autism, Susceptibility To, 20

AUTS20

{Autism, Susceptibility To, 20}
Pervasive Developmental Disorder

Pervasive Development Disorder

Pervasive Developmental Disorders

Pervasive Child Development Disorders

Autistic Behavior

Autism Spectrum Disorders
Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Pitt-Hopkins-Like Syndrome 1

Cortical Dysplasia-Focal Epilepsy Syndrome

CDFES

PTHSL1

Cdfe Syndrome

Pitt-Hopkins Like Syndrome 1

Pitt-Hopkins-Like Syndrome-1

Cntnap2-Related Developmental And Epileptic Encephalopathy

Cntnap2-Related Dee

Mesh

D006985

Mesh

D008607
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09339 NLGN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19024 Nlgn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25513 Nlgn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NLGN1 VGNC VGNC:97209
Felis catus NLGN1 VGNC VGNC:63821
Bos taurus NLGN1 VGNC VGNC:58395
Macaca mulatta NLGN1 VGNC VGNC:75174
Rattus norvegicus NLGN1 RGD RGD:621117
Mus musculus NLGN1 MGD MGI:2179435
Others NLGN1 NCBI
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